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NCT05676047: STAR-C3
Cognitive Rehabilitation for Long COVID
NA trial testing Cognitive Rehabilitation in Long COVID in 100 participants. Completed in 21 January 2025.
21 January 2025
Quick facts
| Lead sponsor | McMaster University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 100 |
| Start date | 1 May 2023 |
| Primary completion | 21 January 2025 |
| Estimated completion | 21 January 2025 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Cognitive Rehabilitation
- Education
Conditions studied
- Long COVID — all drugs for Long COVID →
Sponsor
McMaster University
Who can join
Adults 18 to 100, any sex, with Long COVID. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators are comparing two different methods for helping adults with Long Coronavirus (COVID) also known as Post-Coronavirus Syndrome or Post-Coronavirus Condition manage everyday cognitive challenges. Cognitive rehabilitation is a type of therapy that helps people who have challenges with everyday thinking because of a brain injury. One of the investigators on this project along with colleagues in the United States (US) have developed a streamlined version of cognitive rehabilitation therapy for mild traumatic brain injury (mTBI) that can be completed in person or virtually and takes place over a 3-week period. The therapy was originally designed for adults with mTBI. The investigators want to know if it can also be used to treat people with cognitive complaints from Long COVID. The investigators will provide education materials only to one group and individual cognitive rehabilitation delivered by a trained Speech Language Pathologist (SLP) or Occupational Therapist (OT) to the other group. The investigators want to find out whether the individual therapy is as feasible and accessible than the usual educational material. What the investigators learn in this study may help treat day-to-day thinking challenges in Long COVID.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Breaking through the noise: how to unveil the cognitive impact of long COVID on pre-existing conditions with executive dysfunctions?
Jose C. · · 2024 · cited 1× · PMID 38846912 · DOI 10.3389/fpsyt.2024.1390214
Verify or expand the search:
- PubMed search for NCT05676047
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Cognitive Rehabilitation
Trials testing the same drug.
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- NCT07160218 — Effects of tDCS and Cognitive Rehabilitation on Cognition and Neural Plasticity in MS Patients · NA · completed
- NCT06069882 — Cognitive Rehabilitation for People With Mild-to-moderate Dementia · NA · unknown
Other recruiting trials for Long COVID
Currently open trials in the same condition.
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- NCT07316127 — Immunoadsorption in Autoimmune Long COVID · Phase 2 · recruiting
- NCT07435805 — Long-Term Health Effects of Previous COVID-19 in Patients Undergoing Preoperative Anesthesia Evaluation · recruiting
- NCT07278206 — Brain Stimulation in Long COVID · NA · recruiting
Other McMaster University trials
Trials by the same sponsor.
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- NCT07408128 — Partner4Exercise Randomized Controlled Trial · Phase 2, PHASE3 · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05676047 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by McMaster University
- Last refreshed: 23 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05676047.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing