Last reviewed · How we verify
NCT05675423
Imaging Characterization of the Biomechanical Coupling of Brain and Skull
trial in Traumatic Brain Injury (Tbi). Withdrawn.
12 September 2024
Quick facts
| Lead sponsor | National Institutes of Health Clinical Center (CC) |
|---|---|
| Status | Withdrawn |
| Study type | OBSERVATIONAL |
| Start date | 12 September 2024 |
| Primary completion | 12 September 2024 |
| Estimated completion | 12 September 2024 |
| Sites | 1 location across United States |
Conditions studied
- Traumatic Brain Injury (Tbi) — all drugs for Traumatic Brain Injury (Tbi) →
- Traumatic Meningeal Enhancement (Tme) — all drugs for Traumatic Meningeal Enhancement (Tme) →
Sponsor
National Institutes of Health Clinical Center (CC)
Who can join
Adults 21 to 65, any sex, with Traumatic Brain Injury (Tbi) or Traumatic Meningeal Enhancement (Tme). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Background: Traumatic brain injury (TBI) affects over 1.7 million people in the United States each year. Many cases are mild, but people with a history of TBI may have long-term symptoms; they are also known to be more susceptible to future concussions. Researchers are working to understand how TBI affects tissues in and around the brain over the long term. This natural history study will investigate how a TBI may change the stiffness of the brain and its surrounding connective tissues. Objective: To see how the brain and connective tissues respond to small head movements in people with and without a prior TBI. Eligibility: People aged 21 to 65 years with a history of TBI. People with no history of TBI are also needed. Design: Participants will have 1 clinic visit that will last about 4 hours. Participants will have a physical exam. They answer questions to make sure it is safe for them to have a magnetic resonance imaging (MRI) scan of their brain. They will have an MRI scan in 2 parts. During the first part, participants will lie on a table that slides into a large tube. They will hear loud knocking noises. They may wear earplugs or earmuffs. They will lie still for 15 minutes at a time. They will be in the tube for about up to 75 minutes. The second part is called magnetic resonance elastography (MRE). Participants will lie with their head on a pillow that vibrates gently. This test will take 10 minutes. Participants will answer questions about how they feel 1 or 2 days after the procedure.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05675423
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other National Institutes of Health Clinical Center (CC) trials
Trials by the same sponsor.
- NCT06998134 — Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults · recruiting
- NCT05473429 — Characterization of Nociception Phenotype in Individuals With Intellectual Disability · NA · recruiting
- NCT07295795 — Blood Sampling Pre- and Post-Propofol Administration to Characterize the Blood Proteome Using Different Research Assays · recruiting
- NCT05663320 — A Study of a Virtual Education-Based Transition Intervention to Improve Transition Readiness in Adolescent and Young Adu · NA · withdrawn
- NCT06778252 — UrbanHEAT: Health Behaviors, Outcomes, and Disparities in Individually Experienced Temperature Across an Urban Community · withdrawn
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05675423 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Institutes of Health Clinical Center (CC)
- Last refreshed: 3 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05675423.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing