NCT05674214 is a clinical trial in Twin; Pregnancy, Affecting Fetus or Newborn, sponsored by The Third Affiliated Hospital of Guangzhou Medical University.

Who is sponsoring NCT05674214?

NCT05674214 is sponsored by The Third Affiliated Hospital of Guangzhou Medical University.

What condition does NCT05674214 study?

NCT05674214 studies Twin; Pregnancy, Affecting Fetus or Newborn.

Is NCT05674214 still recruiting?

NCT05674214 is currently completed. Last updated 7 June 2023.

Last reviewed 2023-06-07 · How we verify

NCT05674214

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Birth Weight-discordance in Twins Pregnancy: a Multicenter Retrospective Study

Completed Last updated 7 June 2023

What this trial tests

trial in Twin; Pregnancy, Affecting Fetus or Newborn in 13,440 participants. Completed in 25 November 2022.

Timeline

10 September 2020

Primary endpoint
1 October 2022

25 November 2022

Quick facts

Lead sponsor	The Third Affiliated Hospital of Guangzhou Medical University
Status	Completed
Study type	OBSERVATIONAL
Enrollment	13,440
Start date	10 September 2020
Primary completion	1 October 2022
Estimated completion	25 November 2022
Sites	1 location across China

Conditions studied

Twin; Pregnancy, Affecting Fetus or Newborn — all drugs for Twin; Pregnancy, Affecting Fetus or Newborn →

Sponsor

The Third Affiliated Hospital of Guangzhou Medical University

Who can join

Adults 1 Day to 28 Days, any sex, with Twin; Pregnancy, Affecting Fetus or Newborn. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The rate of twin pregnancies in China has increased by 50 percent over the past decade and now stands at about 3 percent. This is significantly higher than the European and American countries. There are significant differences in birth weight of some newborns, that is, birth weight-discordance in twin pregnancies (BWDT). BWDT was significantly associated with fetal death, preterm birth, neonatal death, and neonatal complications. Existing studies mainly focus on the perinatal outcomes of mothers and infants with BWDT, or are reported from small samples in developed countries. The investigators are aware of the need to further explore the occurrence of birth weight inconsistency and adverse neonatal outcomes in China with a large sample. Through retrospective study design, the investigators will collect clinical data of live twin births at multiple study sites, investigate the incidence of BWDT, and analyze its adverse outcomes.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Association of Birthweight Discordance with Adverse Birth Outcomes Among Live-Born Twins: A Multi-Center Study in China.
Shi B, Tan X, Chen Q, Lu D, et al · · 2025 · PMID 40655470 · DOI 10.2147/clep.s526154

Verify or expand the search:

Other recruiting trials for Twin; Pregnancy, Affecting Fetus or Newborn

Currently open trials in the same condition.

NCT05952583 — Selective Fetal Growth Restriction in Monochorionic Twins - an International Investigation · recruiting
NCT06053697 — Is the Vaginal Microbiome and Metabolome Associated With Spontaneous Preterm Birth (sPTB) in Multiple Pregnancies? · active not recruiting

Other The Third Affiliated Hospital of Guangzhou Medical University trials

Trials by the same sponsor.

NCT07533929 — Incidence and Predictors of Elevated ALT in Postpartum CHB Mothers · not yet recruiting
NCT07025954 — Planned Delivery at 37 Versus 36 Weeks in Pregnancies With Placenta Previaand Accreta · NA · recruiting
NCT06711601 — Ultrasound Evaluation of Two Anatomic Landmarks in Spinal Anesthesia for Cesarean Section: the Posterior Superior Iliac · recruiting
NCT06420427 — Dynamic Monitoring of ctDNA and HPV DNA in Plasma for the Early Prediction of Recurrence After Cervical Cancer Surgery · recruiting
NCT06383858 — The Project of Gestational Hypertension and Preeclampsia Screening and Prevention Center · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05674214 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The Third Affiliated Hospital of Guangzhou Medical University
Last refreshed: 7 June 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05674214.

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