NCT05671146

An Evaluation of the Graded Weight-bearing Exercise in Patients With Knee Osteoarthritis.

Completed NA Last updated 10 October 2023

What this trial tests

NA trial testing anti-gravity treadmill in Knee Osteoarthritis in 45 participants. Completed in 10 July 2023.

Timeline

25 December 2022

Primary endpoint
28 March 2023

10 July 2023

Quick facts

Lead sponsor	Imam Abdulrahman Bin Faisal University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	sequential
Masking	single
Primary purpose	treatment
Enrollment	45
Start date	25 December 2022
Primary completion	28 March 2023
Estimated completion	10 July 2023
Sites	1 location across Saudi Arabia

Drugs / interventions tested

• anti-gravity treadmill
• Weight-bearing exercises for knee flexors and extensors
• Non weight-bearing exercises for knee flexors and extensors

Conditions studied

• Knee Osteoarthritis — all drugs for Knee Osteoarthritis →

Sponsor

Imam Abdulrahman Bin Faisal University

Who can join

Adults 40 to 60, any sex, with Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background: Knee osteoarthritis is the most common disorder impacting the synovial joint. The prevalence of osteoarthritis rises with age, and its consequences on health and socioeconomic are significant, which emphasize the need for clinical and cost-effective treatments for patients with knee OA. Knee OA is a widespread joint arthritis disease combined with many clinical features such as pain, decreased joint proprioception and might lead to loss of function and disability.

Aim: To evaluate the effect of a 6-weeks supervised graded weight-bearing exercise program on pain, function, proprioception, muscle strength in patients with knee osteoarthritis.

Material and Method: Thirty-six patients with chronic knee osteoarthritis with age ranging 40-60 years will be recruited from the physical therapy department and randomized into three groups. Group I: will receive graded weight-bearing exercise using the anti-gravity treadmill combined with open kinetic chain exercises. Group II will receive closed kinetic chain exercises with open kinetic chain exercises while group III will receive open kinetic chain exercises only i.e: stretching and strengthening exercises. The outcome measures will be pain, function, proprioception, and muscle strength.

Statistical analysis: To detect changes in the dependent variables within and between groups, one-way repeated measures Multivariate analysis will be applied. If there is a significant change within groups or between tests, the post hoc Bonferroni test will be used to detect the significance between each group and/or each level of measurement. The level of significance is p\<0.05 and confidence interval CI 95%.

Study Design: Single-blinded, randomised control trial.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Effectiveness of Graded Weight-Bearing Exercises on Pain, Function, Proprioception, and Muscle Strength in Individuals with Knee Osteoarthritis: A Randomized Controlled Trial.
   Fadil A, Muaidi QI, Alayat MS, Subahi MS, et al · · 2025 · PMID 41227082 · DOI 10.3390/jcm14217685