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NCT05669612: Promephy
Promephy - Metabolic Fate of Plant-based Proteins
NA trial testing Dairy based protein in Amino Acid Change in 20 participants. Completed in 17 February 2024.
17 February 2024
Quick facts
| Lead sponsor | Anglia Ruskin University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | basic science |
| Enrollment | 20 |
| Start date | 2 May 2023 |
| Primary completion | 17 February 2024 |
| Estimated completion | 17 February 2024 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Dairy based protein
- Mixed protein
- Plant-based protein 1
- Plant-based protein 2
Conditions studied
- Amino Acid Change — all drugs for Amino Acid Change →
- Gastrointestinal Dysfunction — all drugs for Gastrointestinal Dysfunction →
Sponsor
Anglia Ruskin University
Who can join
Adults 18 to 50, any sex, with Amino Acid Change or Gastrointestinal Dysfunction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The PROMEPHY study aims to assess differences between animal versus plant-based proteins on metabolic and physiological parameters in healthy adults. It is envisaged that the results from this study will provide important and novel insights into the potential health-benefits of regular consumption of plant-based proteins. This may enable future application in products available to the consumer. The main objective of this study is to compare the changes in serum essential amino acid bioavailability after two weeks of daily consumption of a plant-based protein mix with the changes in serum essential amino acid bioavailability after two weeks of daily consumption of a milk protein isolate. In addition this study will aim to assess the impact of different protein sources on gut microbiota and proteome composition to determine the potential health impact of consumption of plant-based proteins.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Comparative effects of dairy, hybrid and plant-based protein blends (including fibre fortification) on amino acid profiles and gut microbiota adaptations: The Promephy study.
Roberts J, Lillis J, Mercer J, Mercer H, et al · · 2026 · PMID 41799254 · DOI 10.1016/j.crfs.2026.101359
Verify or expand the search:
- PubMed search for NCT05669612
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Amino Acid Change
Currently open trials in the same condition.
- NCT06394687 — The Digestion of Protein Powders in Healthy Participants Using SIMBA and LIMBA Capsule · NA · active not recruiting
Other Anglia Ruskin University trials
Trials by the same sponsor.
- NCT07161570 — Virtual Reality Digital Therapeutics for Seasonal Affective Disorder · NA · not yet recruiting
- NCT07008586 — The Impact of OliPhenolia® Supplementation on Exercise Induced Inflammation and Functional Movement in Humans. · NA · completed
- NCT07210099 — The Effect of Short-term Supplementation of OliPhenolia® on Fat Oxidation · NA · recruiting
- NCT06844396 — The Impact of NICU Music Therapy for Preterm Infants and Caregivers · NA · completed
- NCT07497113 — The Effects of Commercially Available High Protein Drink on Amino Acid Bioavailability and Recovery From Muscle Fatiguin · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05669612 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Anglia Ruskin University
- Last refreshed: 5 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05669612.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing