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NCT05669287

Defining a Vascular Phenotype of Pancreatic Ductal Adenocarcinoma With CT Perfusion Using Quantitative Radiomics

Status unknown NA Last updated 3 May 2023
What this trial tests

NA trial testing CT Perfusion in PDAC - Pancreatic Ductal Adenocarcinoma in 125 participants. Status unknown.

Timeline
22 December 2017
Primary endpoint
31 December 2022
1 June 2023

Quick facts

Lead sponsorRadboud University Medical Center
PhaseNA
StatusStatus unknown
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposediagnostic
Enrollment125
Start date22 December 2017
Primary completion31 December 2022
Estimated completion1 June 2023
Sites1 location across Netherlands

Drugs / interventions tested

Conditions studied

Sponsor

Radboud University Medical Center

Who can join

18 and older, any sex, with PDAC - Pancreatic Ductal Adenocarcinoma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

With CT-perfusion(CTP) it is possible to visualize the enhancement pattern of the tumor. The perfusion CT, interleaved with a routine contrast enhanced CT (CECT) will be performed at diagnosis in all patients (goal: n=125 patients) and at the first follow-up at 3 months in patients treated with systemic therapy (goal: n=50 patients). Also, the histopathology will be collected for resected tumors to perform histopathology analysis. CTP parameters will be correlated to immunohistological findings and clinical outcome. The main goal of the study is to create an AI-assisted method to classify patients with a vascular phenotype of pancreatic ductal adenocarcinoma (PDAC). The investigators expect that this phenotype can be used to predict overall survival and chemotherapy response.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Automated Quantitative Analysis of CT Perfusion to Classify Vascular Phenotypes of Pancreatic Ductal Adenocarcinoma.
    Perik T, Alves N, Hermans JJ, Huisman H. · · 2024 · cited 1× · PMID 38339328 · DOI 10.3390/cancers16030577

Verify or expand the search:

Other trials of CT Perfusion

Trials testing the same drug.

Other recruiting trials for PDAC - Pancreatic Ductal Adenocarcinoma

Currently open trials in the same condition.

Other Radboud University Medical Center trials

Trials by the same sponsor.

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Data sources for this page

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