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NCT05667337: CLP-PEG-MPC
Open-label Prospective Clinical Trial Evaluating the Safety and Efficacy of Biosynthetic CLP-PEG-MPC Corneal Implants in Patients Undergoing High-risk Deep Anterior Lamellar Keratoplasty.
NA trial testing CLP-PEG-MPC in High-risk Corneal Transplantation. Withdrawn.
1 January 2040
Quick facts
| Lead sponsor | Centre hospitalier de l'Université de Montréal (CHUM) |
|---|---|
| Phase | NA |
| Status | Withdrawn |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Start date | 1 January 2026 |
| Primary completion | 1 January 2040 |
| Estimated completion | 1 June 2040 |
Drugs / interventions tested
- CLP-PEG-MPC
- Human donor cornea penetrating keratoplasty
Conditions studied
- High-risk Corneal Transplantation — all drugs for High-risk Corneal Transplantation →
- Corneal Blindess — all drugs for Corneal Blindess →
- Corneal Inflammation — all drugs for Corneal Inflammation →
- Deep Anterior Lamellar Keratoplasty — all drugs for Deep Anterior Lamellar Keratoplasty →
Sponsor
Centre hospitalier de l'Université de Montréal (CHUM)
Who can join
Adults 18 to 99, any sex, with High-risk Corneal Transplantation or Corneal Blindess. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is an open-label and prospective clinical trial, in which a maximum of 5 eyes of 5 patients will receive a CLP-PEG-MPC synthetic cornea during deep anterior lamellar keratoplasty (DALK) surgery and will be followed up over 24 months.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05667337
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05667337 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centre hospitalier de l'Université de Montréal (CHUM)
- Last refreshed: 28 December 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05667337.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing