NCT05664321

Influence of Adiposity and Other Factors on the Gut Microbiota Composition

Completed Last updated 23 December 2022

What this trial tests

trial testing Observational, case-control study in Obesity in 92 participants. Completed in 1 December 2021.

Timeline

1 January 2019

Primary endpoint
1 March 2020

1 December 2021

Quick facts

Lead sponsor	King Saud University
Status	Completed
Study type	OBSERVATIONAL
Enrollment	92
Start date	1 January 2019
Primary completion	1 March 2020
Estimated completion	1 December 2021
Sites	1 location across Saudi Arabia

Drugs / interventions tested

• Observational, case-control study

Conditions studied

• Obesity — all drugs for Obesity →
• Metabolic Syndrome — all drugs for Metabolic Syndrome →

Sponsor

King Saud University

Who can join

Adults 18 to 25, female only, with Obesity or Metabolic Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

People who are overweight are getting more and more common in every region of the world. However, despite significant progress being made in the treatment options available for overweight, the worldwide incidence of overweight has not gone down, and the challenge of overweight has become a worrisome phenomenon of our times. Additionally, the process that underlie this illness and the etiological variables are not fully comprehended. As a result, it is absolutely necessary to determine the factors that contribute to obesity and define the responsibilities that each play. Researchers have devoted a significant portion of the better part of the last decade to studying the microbiota of the gut to determine whether or not it may play a factor in the development of obesity. Across spite of this, there is a paucity of accessible epidemiological data in Saudi Arabia. In addition, the relationship between the composition of the "gut microbiota" and obesity indices in youthful women of reproductive age is little understood. In view of this, we decided to conduct a case study utilizing whole-genome shotgun sequencing to compare the gut microbiota of obese women from Saudi Arabia with that of healthy control participants. Our findings shed light on the significance of the gut microbiota in obesity and provide useful insight into the creation of a method for the therapy of obesity by means of microbiota transfer of fecal, antibiotics, probiotics, and prebiotics. In addition, these data reveal prospective targets for guiding the selection of probiotic strains for the needed gut microbiota regulation in the obesity therapy.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Red and White Meat Intake in Relation to Gut Flora in Obese and Non-Obese Arab Females.
   Almajed J, Al-Musharaf S, Abudawood M, Sabico S, et al · · 2023 · cited 1× · PMID 36673337 · DOI 10.3390/foods12020245