NCT05664282: CROWDIT

Orthodontic Treatment in Adolescents With Crowding and Displaced Teeth

Active, enrolled NA Last updated 23 December 2022

What this trial tests

NA trial testing Damon self-ligating brackets in Crowding, Tooth in 131 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 May 2016

Primary endpoint
31 December 2027

31 December 2027

Quick facts

Lead sponsor	Malmö University
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	131
Start date	1 May 2016
Primary completion	31 December 2027
Estimated completion	31 December 2027

Drugs / interventions tested

• Damon self-ligating brackets
• Victory self-ligating brackets

Conditions studied

• Crowding, Tooth — all drugs for Crowding, Tooth →
• Orthodontic — all drugs for Orthodontic →

Sponsor

Malmö University

Who can join

Adults 12 to 17, any sex, with Crowding, Tooth or Orthodontic. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose is to fill knowledge gaps identified for orthodontic treatment using a novel study design that has not been implemented in the dental field or in orthodontics. The study design comprises an analysis, where outcomes of two techniques are assessed at several efficacy levels by different methods. Moreover, the project is designed to include a longtime follow-up that is unique in orthodontic treatment. The aim is to compare two techniques with buccally fixed appliance in a multicenter RCT of adolescents aged 12 to 17 years with crowding and tooth displacement. In the intervention group, patients will be treated with a self-ligating bracket system, and in the control group with a conventional bracket system. Outcomes will be assessed from the clinical, patients' and economic perspectives as:

* Tooth alignment, function and adverse side effects
* Patients' perception of pain, function and quality of life
* Cost-effectiveness.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. Evaluation of External Apical Root Resorption and the Relevance of Intermediate Radiography in Non-Extraction Treatment With Fixed Appliances for Adolescents With Crowding: A Multicenter Randomised Controlled Trial Using CBCT.
   Johansson K, Christell H, Brechter A, Paulsson L. · · 2025 · cited 2× · PMID 39899339 · DOI 10.1111/ocr.12903
2. Reliability and agreement of root length measurements during orthodontic treatment in images from different CBCT machines using multiplanar reconstruction.
   Johansson K, Paulsson L, Christell H. · · 2024 · cited 1× · PMID 39228399 · DOI 10.2340/biid.v11.41161
3. Oral health-related quality of life, experience and satisfaction in adolescents treated for dental crowding with self-ligating or conventional fixed appliances: a multicentre randomized controlled trial
   · 2026
4. Oral health-related quality of life, experience and satisfaction in adolescents treated for dental crowding with self-ligating or conventional fixed appliances: a multicentre randomized controlled trial.
   Bokander Matilainen L, Johansson K, Petrén S, Brechter A, et al · · 2026 · PMID 42257436 · DOI 10.1093/ejo/cjag040
5. Treatment Effects and Treatment Time in Adolescents With Crowded and Displaced Teeth Treated With Fixed Appliance Systems Without Extractions: A Multi-Centre Randomised Controlled Trial.
   Matilainen LB, Johansson K, Wiaderny M, Brechter A, et al · · 2025 · PMID 40698883 · DOI 10.1111/ocr.70005