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Detection of Specific Polysaccharide Antibody Deficiency in Adult Patients With Unexplained Recurrent and/or Severe Bacterial Infections (DETECT)
The DETECT study aims to demonstrate the importance of detecting SPAD in adult patients with recurrent benign and/or severe unexplained bacterial upper/lower respiratory tract infections. Unlike children in whom the deficit may be transient, long-term strategies are warranted in SPAD adult patients to prevent severe infections and lung disability. Beyond the diagnosis of this still unrecognized PID in adult patients, we want to assess the impact of prophylactic antibiotics or IgRT on infections prevention and on quality of life in adult patients with the most severe clinical phenotypes, recurrent infections with high frequency of antibiotics take and/or recurrent infections with complications like bronchiectasis and/or severe infections requiring hospitalizations.
Details
| Lead sponsor | University Hospital, Lille |
|---|---|
| Status | NOT_YET_RECRUITING |
| Enrolment | 99 |
| Start date | 2023-03 |
| Completion | 2026-06 |
Conditions
- Specific Antibody Deficiency
- Predominantly Antibody Deficiencies
Interventions
- Diagnosis of SPAD using immunization with PPV23
Primary outcomes
- Diagnosis of SPAD according to the AAAAI proposed consensus criteria for an impaired selective response to PS using immunization with PPV23 and assessment of anti-PnPS IgG response by the serotype-specific WHO-standardized ELISA 4 — to 8 weeks after immunization