Who is sponsoring NCT05663125?

NCT05663125 is sponsored by Beijing Tiantan Hospital.

What drugs are being tested in NCT05663125?

Interventions in NCT05663125: Laser interstitial thermal therapy, Temozolomide.

What condition does NCT05663125 study?

NCT05663125 studies Recurrent Glioblastoma.

Is NCT05663125 still recruiting?

NCT05663125 is currently status unknown. Last updated 23 December 2022.

Last reviewed 2022-12-23 · How we verify

NCT05663125

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

LITT Combined With Early Use of Temozolomide for Recurrent Glioblastomas

Status unknown Phase 1, PHASE2 Last updated 23 December 2022

What this trial tests

Phase 1, PHASE2 trial testing Laser interstitial thermal therapy in Recurrent Glioblastoma in 10 participants. Status unknown.

Timeline

1 December 2022

Primary endpoint
1 December 2023

30 December 2024

Quick facts

Lead sponsor	Beijing Tiantan Hospital
Phase	Phase 1, PHASE2
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	10
Start date	1 December 2022
Primary completion	1 December 2023
Estimated completion	30 December 2024
Sites	1 location across China

Drugs / interventions tested

Laser interstitial thermal therapy
Temozolomide (temozolomide) — full drug profile →

Conditions studied

Recurrent Glioblastoma — all drugs for Recurrent Glioblastoma →

Sponsor

Beijing Tiantan Hospital

Who can join

Adults 18 to 75, any sex, with Recurrent Glioblastoma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to investigate the safety and efficacy of Laser Interstitial Thermal Therapy (LITT) combined with postoperative early use of temozolomide in treating recurrent glioblastomas.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma.
Mokarram N, Case A, Hossainy NN, Lyon JG, et al · · 2025 · cited 17× · PMID 39790893 · DOI 10.1038/s43246-024-00721-y
Therapeutic manipulation and bypass of the blood-brain barrier: powerful tools in glioma treatment.
Giantini-Larsen AM, Pandey A, Garton ALA, Rampichini M, et al · · 2025 · cited 8× · PMID 39877748 · DOI 10.1093/noajnl/vdae201
Mitochondrial Iron Metabolism as a Potential Key Mediator of PD-L1 Thermal Regulation.
Keeler G, Owusu SB, Zanaty M, Petronek MS. · · 2024 · cited 1× · PMID 39594692 · DOI 10.3390/cancers16223736

Verify or expand the search:

Other trials of Laser interstitial thermal therapy

Trials testing the same drug.

NCT07132203 — Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Brain Metastases Trial · NA · completed

Other recruiting trials for Recurrent Glioblastoma

Currently open trials in the same condition.

NCT07480941 — Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma · Phase 1 · recruiting
NCT07209241 — Different Approaches for CART-EGFR-IL13Ra2 Dosing in Recurrent GBM · Phase 1 · recruiting
NCT06910306 — Alpha Radiation Emitters Device (DaRT) for the Treatment of Recurrent Glioblastoma · NA · recruiting
NCT07193628 — B7H3/IL13Ra2 Bispecific Armored Chimeric Antigen Receptor T-Cell Therapy Study for Recurrent/Refractory Glioblastoma · Phase 1 · recruiting
NCT07076472 — Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of P · EARLY_PHASE1 · recruiting

Other Beijing Tiantan Hospital trials

Trials by the same sponsor.

NCT07341854 — Dexamethasone Palmitate for Postoperative Pain · NA · not yet recruiting
NCT07527013 — Stratified Blood Pressure Management Strategy After Endovascular Treatment for Acute Ischemic Stroke · Phase 3 · not yet recruiting
NCT07520370 — Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain Tumor · NA · not yet recruiting
NCT07526987 — Efficacy and Safety of Minocycline in Patients With Acute Ischaemic Stroke Receiving Intravenous Thrombolysis · Phase 3 · not yet recruiting
NCT07591207 — The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Laparoscopic Surgery · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05663125 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Beijing Tiantan Hospital
Last refreshed: 23 December 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05663125.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing