Effectiveness of Stromal Vascular Fraction (SVF) and Platelet -Rich Plasma (PRP) in Patients With Knee Osteoarthritis: Study Protocol for a Phase III, Prospective, Randomized, Controlled Multi-center Study : (SPOST Study)

NCT05660824 Phase 4 NOT_YET_RECRUITING

This multicenter, randomized, triple-blind, controlled trial, will enroll 108 patients who will block-randomized in a 1:1 ratio to either the intervention or control group. The main question to answer are the clinical efficacy of SVF as adjuvant therapy to PRP on functionality and tissue regeneration for knee osteoarthritis.

Details

Lead sponsor	Adrien Schwitzguebel
Phase	Phase 4
Status	NOT_YET_RECRUITING
Enrolment	108
Start date	2025-07
Completion	2027-08

Conditions

• Osteoarthritis

Interventions

• Stromal Vascular Fraction infiltration
• Plattelet Rich Plasma infiltration

Primary outcomes

• WOMAC — 6 months
  Functional improvement measured with the 0%-100% normalized Western Ontario McMaster Universities Osteoarthritis Index, where 0% indicates complete absence of symptoms and 100% indicates maximal possible symptoms severity