Who is sponsoring NCT05658861?

NCT05658861 is sponsored by Purdue University.

What drugs are being tested in NCT05658861?

Interventions in NCT05658861: Milk containing A1 and A2 beta-casein, Milk containing only A2 beta-casein.

What condition does NCT05658861 study?

NCT05658861 studies Lactose Intolerance, Adult Type.

Is NCT05658861 still recruiting?

NCT05658861 is currently completed. Last updated 21 November 2023.

Last reviewed 2023-11-21 · How we verify

NCT05658861

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparing the Gastric Transit of Commercial Milk and A2 Milk

Completed NA Last updated 21 November 2023

What this trial tests

NA trial testing Milk containing A1 and A2 beta-casein in Lactose Intolerance, Adult Type in 10 participants. Completed in 1 December 2022.

Timeline

21 June 2021

Primary endpoint
6 October 2022

1 December 2022

Quick facts

Lead sponsor	Purdue University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	triple
Primary purpose	other
Enrollment	10
Start date	21 June 2021
Primary completion	6 October 2022
Estimated completion	1 December 2022
Sites	1 location across United States

Drugs / interventions tested

Milk containing A1 and A2 beta-casein
Milk containing only A2 beta-casein

Conditions studied

Lactose Intolerance, Adult Type — all drugs for Lactose Intolerance, Adult Type →

Sponsor

Purdue University

Who can join

Adults 18 to 65, any sex, with Lactose Intolerance, Adult Type. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Cow's milk contains two types of β-casein: A1 and A2. The μ-opioid peptide BCM-7 is released from A1 but not from A2. BCM-7 is associated with slower gastrointestinal transit and hence increased gastrointestinal transit times. Lactose maldigesters reported an increase in abdominal pain due to consumption of milk containing A1 beta-casein as compared to milk containing only A2 beta-casein. The hypothesis of this study is that the differential abdominal pain is due to the differential gastric transit. This is a double-blinded, randomized, controlled trial conducted to determine if the transit of A1 β-casein milk is modified in the stomach as compared to milk with only A2 β-casein.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Gastric Emptying of New-World Milk Containing A1 and A2 Β-Casein Is More Rapid as Compared to Milk Containing Only A2 Β-Casein in Lactose Maldigesters: A Randomized, Cross-Over Trial Using Magnetic Resonance Imaging.
Ramakrishnan M, Zhou X, Dydak U, Savaiano DA. · · 2023 · cited 10× · PMID 36839159 · DOI 10.3390/nu15040801

Verify or expand the search:

Other trials of Milk containing A1 and A2 beta-casein

Trials testing the same drug.

NCT05669274 — Comparing the Adaptation of Commercial Milk and A2 Milk in Lactose Maldigesters · NA · unknown

Other recruiting trials for Lactose Intolerance, Adult Type

Currently open trials in the same condition.

NCT06724705 — Testing the Capability of the Smart Underwear Device to Detect Increased Microbiome Activity Following Lactose Consumpti · NA · recruiting

Other Purdue University trials

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05658861 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Purdue University
Last refreshed: 21 November 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05658861.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing