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NCT05653921
Prospective Study to Validate the Imaging Biomarker for NCP (R33)
trial testing In vivo confocal microscopy (IVCM) in Dry Eye Syndromes in 438 participants. Suspended.
31 July 2026
Quick facts
| Lead sponsor | Tufts Medical Center |
|---|---|
| Status | Suspended |
| Study type | OBSERVATIONAL |
| Enrollment | 438 |
| Start date | 16 December 2022 |
| Primary completion | 31 July 2026 |
| Estimated completion | 31 October 2026 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- In vivo confocal microscopy (IVCM)
Conditions studied
- Dry Eye Syndromes — all drugs for Dry Eye Syndromes →
- Corneal Disease — all drugs for Corneal Disease →
Sponsor
Tufts Medical Center
Who can join
18 and older, any sex, with Dry Eye Syndromes or Corneal Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study is establish the reliability and clinical utility of microneuromas as identified via in vivo confocal microscopy as the diagnostic biomarker for NCP.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Development and validation of a deep learning model for diagnosing neuropathic corneal pain via in vivo confocal microscopy.
Koseoglu ND, Chen E, Tuwani R, Kompa B, et al · · 2025 · cited 1× · PMID 40369269 · DOI 10.1038/s41746-025-01577-3
Verify or expand the search:
- PubMed search for NCT05653921
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Tufts Medical Center trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05653921 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tufts Medical Center
- Last refreshed: 7 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05653921.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing