Last reviewed · How we verify
NCT05652218: REINVENT
REsynchronization Comparison In LBBB and Normal or Mildly Reduced VENTricular Function With CRT (REINVENT-CRT)
NA trial testing LB-CRT in Left Ventricular Ejection Fraction in 21 participants. Participants enrolled and being followed up; not accepting new ones.
28 February 2026
Quick facts
| Lead sponsor | Inova Health Care Services |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | other |
| Enrollment | 21 |
| Start date | 26 February 2023 |
| Primary completion | 28 February 2026 |
| Estimated completion | 31 March 2026 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- LB-CRT
- BIV-CRT
Conditions studied
- Left Ventricular Ejection Fraction — all drugs for Left Ventricular Ejection Fraction →
- Heart Failure (HF) — all drugs for Heart Failure (HF) →
- Left Bundle-Branch Block — all drugs for Left Bundle-Branch Block →
Sponsor
Inova Health Care Services — full company profile →
Who can join
Eligibility, any sex, with Left Ventricular Ejection Fraction or Heart Failure (HF). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Primary Objective - To determine if implantation of a permanent CRT pacing device (with LB-CRT, or conventional BiV-CRT with a coronary sinus LV lead) can improve electromechanical function, HF symptoms, and natriuretic peptide levels among patients with symptomatic HF, LVEF \> 35%, and LBBB.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Cardiac Resynchronization Therapy and Conduction System Pacing.
O'Neill TG, Tsushima T, Tayal B. · · 2025 · cited 1× · PMID 40364243 · DOI 10.3390/jcm14093212 -
Conduction System Pacing for Heart Failure.
Smith NR, Lynch P, Chelu MG. · · 2024 · PMID 39677397 · DOI 10.14503/thij-24-8469
Verify or expand the search:
- PubMed search for NCT05652218
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other Inova Health Care Services trials
Trials by the same sponsor.
- NCT06564207 — Fostamatinib for Treating Acute Respiratory Distress Syndrome (ARDS) in Hospitalized Adults · Phase 2 · not yet recruiting
- NCT07167199 — Absorbable Staples Versus Conventional Skin Closure in Women Undergoing Cesarean Delivery · NA · not yet recruiting
- NCT07437339 — Volume Reduction for Open Fracture Irrigation · Phase 4 · recruiting
- NCT07485322 — Burn Pit Exposure in Veterans: A Cancer Screening Pilot Study at the Inova Saville Cancer Screening & Prevention Center · NA · not yet recruiting
- NCT07335224 — Men With Prostate Cancer: Optimizing Wellness by Enhanced Relief From Hot Flashes With Acupuncture · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05652218 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Inova Health Care Services
- Last refreshed: 2 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05652218.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing