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NCT05650957: PRoVENT-COP
PRactice of VENTilation in Patients With ARDS Due to COVID-19 vs Pneumonia
trial in Acute Respiratory Distress Syndrome in 7,145 participants. Completed in 1 February 2024.
1 February 2024
Quick facts
| Lead sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 7,145 |
| Start date | 1 August 2022 |
| Primary completion | 1 February 2024 |
| Estimated completion | 1 February 2024 |
| Sites | 6 locations across Netherlands, Brazil, Ireland, Argentina, Spain |
Conditions studied
- Acute Respiratory Distress Syndrome — all drugs for Acute Respiratory Distress Syndrome →
- COVID-19 — all drugs for COVID-19 →
- Pneumonia — all drugs for Pneumonia →
- Mechanical Ventilation Complication — all drugs for Mechanical Ventilation Complication →
Sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) — full company profile →
Who can join
Adults 18 to 100, any sex, with Acute Respiratory Distress Syndrome or COVID-19. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to compare epidemiology, management of invasive ventilation and outcomes in critically ill patients with COVID-19 ARDS and ARDS from another pulmonary infection. The investigators will use individual patient data from four recently published large observational COVID-9 studies, including the 'Practice of VENTilation in COVID-19 patients' (PRoVENT-COVID) study, the 'Epidemiology of COVID-19 patients in the ICU' (EPICCoV) study, the 'SATI-COVID-19 - Clinical Characteristics and Outcomes of Patients With COVID-19 on Mechanical Ventilation in Argentina: a Prospective, Multicenter Cohort Study' and the CIBERESUCICOVID - Personalized Risk and Prognosis Factors and Follow-up at One Year of the Patients Hospitalized in the Spanish Intensive Care Units Infected with COVID -19' study. The investigators will use the individual patient data from ARDS patients with another pulmonary infection from the 'LUNG -SAFE - Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE' study and the 'ERICC - Epidemiology of Respiratory Insufficiency in Critical Care' study.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Epidemiology, ventilation management and outcomes of COVID-19 ARDS patients versus patients with ARDS due to pneumonia in the Pre-COVID era.
van der Ven FLIM, Blok SG, Azevedo LC, Bellani G, et al · · 2024 · cited 12× · PMID 39153979 · DOI 10.1186/s12931-024-02910-2 -
Potentially modifiable ventilatory factors contributing to outcome in patients with pulmonary and extrapulmonary ARDS - An individual patient data analysis.
Dorland G, Blok SG, Swart P, van der Ven FLIM, et al · · 2026 · cited 1× · PMID 41707405 · DOI 10.1016/j.jclinane.2025.112120 -
Outcome patterns in COVID-ARDS compared to ARDS caused by other respiratory infections: an individual patient data analysis of six observational studies
van Oosten P, Blok S, Swart P, Azevedo L, et al · · 2026 -
Epidemiology, Ventilation Management, and Outcomes in Invasively Ventilated Coronavirus Disease 2019 Patients: An Analysis of Four Observational Studies in Four Countries on Two Continents.
Blok SG, Pisani L, Estenssoro E, Ferreira JC, et al · · 2025 · PMID 39842032 · DOI 10.4269/ajtmh.24-0257
Verify or expand the search:
- PubMed search for NCT05650957
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acute Respiratory Distress Syndrome
Currently open trials in the same condition.
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- NCT07326215 — A Study of the Efficacy and Safety of Extracorporeal Carbon Dioxide Removal Using PrismaLung+ · NA · recruiting
- NCT06919484 — The Physiological Effect of RCexp on Ventilation/Perfusion Distribution · recruiting
- NCT07126964 — Extended Prone Positioning for Intubated ARDS · NA · recruiting
Other Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05650957 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Last refreshed: 3 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05650957.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing