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NCT05650645
The Efficacy of Incobotulinum Toxin A Injections for Treatment of Tinnitus: a Randomized Controlled Trial
Phase 2 trial testing incobotulinum toxin A in Tinnitus in 41 participants. Completed in 29 December 2025.
29 December 2025
Quick facts
| Lead sponsor | University of Minnesota |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 41 |
| Start date | 1 January 2023 |
| Primary completion | 29 December 2025 |
| Estimated completion | 29 December 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- incobotulinum toxin A — full drug profile →
- Placebo-Saline
Conditions studied
- Tinnitus — all drugs for Tinnitus →
Sponsor
University of Minnesota
Who can join
18 and older, any sex, with Tinnitus. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Tinnitus is a persistent non-physiologic, non-psychiatric, ringing in the ear that affects up to 20% of the general US population. The purpose of this study is to assess the patient reported effectiveness of Xeomin (incobotulinumtoxinA) injections into the auricular muscles for relief of tinnitus with use of the Tinnitus Handicap Inventory questionnaire.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05650645
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Tinnitus
Currently open trials in the same condition.
- NCT07393880 — Bimodal Electrical-Sound Stimulation and Auditory Training for Chronic Tonal Tinnitus · NA · recruiting
- NCT07071480 — Noninvasive Therapy for Tinnitus · NA · recruiting
- NCT07435298 — Navigated Repetitive TMS for Chronic Tinnitus · NA · recruiting
- NCT07158034 — Investigating EEG as a Biomarker for Tinnitus Improvement After Bimodal Stimulation · NA · recruiting
- NCT07017998 — External Therapy for Tinnitus Management · NA · recruiting
Other University of Minnesota trials
Trials by the same sponsor.
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- NCT03192007 — Multi-Parametric MRI for Renal Transplantation · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05650645 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Minnesota
- Last refreshed: 10 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05650645.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing