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NCT05647707
The Efficacy of L-Carnitine in the Management of Acute Carbon Monoxide Poisoning
Phase 2 trial testing L-Carnitine in Carbon Monoxide Poisoning in 72 participants. Status unknown.
15 April 2023
Quick facts
| Lead sponsor | Alexandria University |
|---|---|
| Phase | Phase 2 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 72 |
| Start date | 15 December 2022 |
| Primary completion | 15 April 2023 |
| Estimated completion | 1 August 2023 |
Drugs / interventions tested
- L-Carnitine — full drug profile →
Conditions studied
- Carbon Monoxide Poisoning — all drugs for Carbon Monoxide Poisoning →
Sponsor
Alexandria University
Who can join
Eligibility, any sex, with Carbon Monoxide Poisoning. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Carbon monoxide (CO) poisoning results in high morbidity and mortality worldwide. CO is described as a "silent killer" because CO is colorless, odorless, and tasteless but highly toxic. The diagnosis of acute CO poisoning depends on the history of exposure to a source of fire in a closed space along with the clinical and laboratory findings. The pathophysiology of CO poisoning is not fully understood; however, it is proved that CO induces hypoxia by forming carboxyhemoglobin (COHb) and shifting the oxygen dissociation curve to the left. The molecular mechanisms of CO poisoning include oxidative injury through the generation of free radicals. In addition, oxygen therapy might enhance the reactive oxygen species (ROS) production and result in reperfusion injury. Free radicals could induce a serious impact on vital organs, including the heart, and brain. L-Carnitine is an endogenous mitochondrial constituent that contributes to normal mitochondrial activities. L-Carnitine is an antioxidant with potent ROS scavenging ability. ROS-mediated pathology of CO suggests that antioxidants are potentially useful agents in the alleviation of CO toxicity. Thus, the current study will investigate the therapeutic efficacy of L-Carnitine in improving the prognosis of acute CO poisoning. The current clinical trial will include patients with moderate and severe acute carbon monoxide poisoning according to Poisoning Severity Score.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05647707
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Related trials
Other trials of L-Carnitine
Trials testing the same drug.
- NCT07492446 — Effects of Carnitine Supplementation on Exercise-Induced Muscle Damage: A Randomized Controlled Trial · NA · completed
- NCT03193125 — Carnitine and Liver Mitochondria Fatty Acid Processing · NA · completed
Other recruiting trials for Carbon Monoxide Poisoning
Currently open trials in the same condition.
- NCT06811675 — The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon M · Phase 4 · recruiting
- NCT06549621 — Cardiotoxicity of Carbon Monoxide in Patients Treated With Hyperbaric Oxygen Therapy · recruiting
- NCT04975867 — Adjunct Targeted Temperature Management in Acute Severe Carbon Monoxide Poisoning · NA · active not recruiting
Other Alexandria University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05647707 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Alexandria University
- Last refreshed: 12 December 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05647707.
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