Last reviewed · How we verify
NCT05643859
Impact of Dietary Fiber Supplementation on Colonic Microbiome
NA trial testing Dietary Fiber in Benign Colorectal Neoplasm in 120 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | OHSU Knight Cancer Institute |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 120 |
| Start date | 1 April 2023 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Dietary Fiber
- Proctoscopy or anoscopy with Biopsy
- Colonoscopy
- Questionnaire Administration
Conditions studied
- Benign Colorectal Neoplasm — all drugs for Benign Colorectal Neoplasm →
- Non-Neoplastic Anal Disorder — all drugs for Non-Neoplastic Anal Disorder →
Sponsor
OHSU Knight Cancer Institute
Who can join
18 and older, any sex, with Benign Colorectal Neoplasm or Non-Neoplastic Anal Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This clinical trial tests whether daily fiber supplementation will change the mucosal microbiome of the colon. The microbiome are microorganisms that live in the human gut. They serve a vital role in maintaining health. Certain microbial strains are associated with the growth of colon polyps, which eventually could go on to form colon cancer. Giving dietary fiber supplements may help prevent precancerous polyps from ever developing.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Diet-driven microbiome changes and physical activity in cancer patients.
Ciernikova S, Sevcikova A, Stevurkova V, Mego M. · · 2023 · cited 11× · PMID 38075222 · DOI 10.3389/fnut.2023.1285516
Verify or expand the search:
- PubMed search for NCT05643859
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Dietary Fiber
Trials testing the same drug.
- NCT06424522 — A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Canc · NA · recruiting
- NCT04211766 — Fiber and Fish Oil Supplements for the Prevention of Colorectal Cancer · NA · completed
- NCT03785860 — The Effects of Dietary Fiber on the Gut Microbiome and HDL Particles of Human Subjects · NA · completed
- NCT03275662 — Fermented and Fiber-rich Food (FeFiFo) Study · NA · completed
Other OHSU Knight Cancer Institute trials
Trials by the same sponsor.
- NCT05453851 — A Surgical Procedure (Total Pancreatectomy) With a Transplant Procedure (Islet Cell Autotransplantation) for the Treatme · Phase 1, PHASE2 · not yet recruiting
- NCT07511504 — Y-90 Radioembolization, Durvalumab, Tremelimumab, and Zanzalintinib for the Treatment of Unresectable and Locally-Advanc · Phase 2 · not yet recruiting
- NCT07434128 — Mammogram Pretreatment With Ulipristal Acetate · Phase 2 · not yet recruiting
- NCT07504835 — GET FIT Together: Testing a Socially Enhanced Exercise Program in Older Men With Prostate Cancer · NA · not yet recruiting
- NCT07498517 — Safety and Efficacy of a Single Dose of Gruticibart to Prevent CRT · Phase 2 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05643859 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by OHSU Knight Cancer Institute
- Last refreshed: 15 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05643859.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing