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NCT05641246
Effect of Topical Diclofenac on Clinical Outcome in Breast Cancer Patients Treated With Capecitabine
Phase 2 trial testing (CARBAMIDE®) in Hand and Foot Syndrome in 86 participants. Completed in 8 December 2023.
15 November 2023
Quick facts
| Lead sponsor | German University in Cairo |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 86 |
| Start date | 8 December 2022 |
| Primary completion | 15 November 2023 |
| Estimated completion | 8 December 2023 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- (CARBAMIDE®) — full drug profile →
- (VOLTAREN®) Emulgel 1% — full drug profile →
Conditions studied
- Hand and Foot Syndrome — all drugs for Hand and Foot Syndrome →
Sponsor
German University in Cairo
Who can join
Adults 18 to 80, female only, with Hand and Foot Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of the study is to evaluate the efficacy of using combination of Urea-based cream (CARBAMIDE®) and topical diclofenac (VOLTAREN®) Emulgel 1% for improving the incidence of Hand-foot syndrome in histologically proven breast cancer Egyptian patients receiving single agent chemotherapy Capecitabine (XELODA ®) and Its effect on improving patients' quality of life.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Nanoemulgel: A Novel Nano Carrier as a Tool for Topical Drug Delivery.
Donthi MR, Donthi MR, Munnangi SR, Krishna KV, et al · · 2023 · cited 73× · PMID 36678794 · DOI 10.3390/pharmaceutics15010164 -
Lactate at the crossroads of tumor metabolism and immune escape: a new frontier in cancer therapy.
Dong Z, Yuan Z, Jin T, Gao C, et al · · 2025 · cited 6× · PMID 41204256 · DOI 10.1186/s12967-025-07272-x
Verify or expand the search:
- PubMed search for NCT05641246
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other German University in Cairo trials
Trials by the same sponsor.
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- NCT05979038 — Clinical Evaluation of the Effect of Metformin in Sepsis · Phase 3 · unknown
- NCT05693597 — Evaluation of the Effect of Nigella Sativa for the Prophylaxis to Radiation Induced Dermatitis in Breast Cancer Patients · Phase 2 · completed
- NCT06812585 — The Effect of Metformin As an Adjuvant Therapy on Immunological Parameters in Egyptian Patients with RRMS: a Pilot Study · Phase 2 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05641246 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by German University in Cairo
- Last refreshed: 3 January 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05641246.
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