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NCT05639686
TIVA vs TXA in Sinus Surgery to Evaluate Operative Blood Loss and Surgical Field Quality
NA trial testing Tranexamic acid injection in Rhinosinusitis Chronic in 100 participants. Status unknown.
31 December 2024
Quick facts
| Lead sponsor | Our Lady of the Lake Hospital |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 100 |
| Start date | 1 January 2023 |
| Primary completion | 31 December 2024 |
| Estimated completion | 1 July 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Tranexamic acid injection — full drug profile →
- Total Intravenous Anesthesia
- Inhalational isoflurane — full drug profile →
Conditions studied
- Rhinosinusitis Chronic — all drugs for Rhinosinusitis Chronic →
- Sinus Cancer — all drugs for Sinus Cancer →
- Sinus Polyp — all drugs for Sinus Polyp →
- Encephalocele — all drugs for Encephalocele →
Sponsor
Our Lady of the Lake Hospital
Who can join
18 and older, any sex, with Rhinosinusitis Chronic or Sinus Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this interventional study is to compare the efficacy (surgical field quality and intra-operative blood loss) or cost of TIVA alone to general inhalational anesthetics with intravenous TXA in patient participants who are undergoing endoscopic sinus surgery. The main questions the study aims to answer are: * Is the surgical field quality better when using TIVA alone compared to general inhalational anesthetics with intravenous TXA? * Is one method more financially advantageous to the participant and the institution compared to the other method? Participants will be randomized into one of the two anesthesia cohorts prior to sinus surgery. One group will be given total intravenous anesthesia (TIVA) alone and the other will be given intravenous tranexamic acid (TXA) followed by general inhalational anesthesia. Researchers will compare the TIVA group to the TXA group to see if one group exhibits a better surgery field viewing quality through a subjective evaluation and measurement of blood loss and also which anesthesia regimen is most cost effective upon conducting a cost analysis.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05639686
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05639686 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Our Lady of the Lake Hospital
- Last refreshed: 23 March 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05639686.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing