NCT05635903

Jet or Vibrating Mesh Nebulisation for Secretion Management in ICU

Status unknown NA Last updated 2 February 2023

What this trial tests

NA trial testing Continuous nebulisation 0.9% saline Aerogen Solo vibrating mesh Nebuliser in Respiratory Failure in 60 participants. Status unknown.

Timeline

22 December 2019

Primary endpoint
22 December 2023

22 December 2023

Quick facts

Lead sponsor	NHS Greater Glasgow and Clyde
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	60
Start date	22 December 2019
Primary completion	22 December 2023
Estimated completion	22 December 2023
Sites	1 location across United Kingdom

Drugs / interventions tested

• Continuous nebulisation 0.9% saline Aerogen Solo vibrating mesh Nebuliser
• Intermittent nebulisation 0.9% saline Aerogen vibrating mesh Solo Nebuliser
• Intermittent standard intermittent nebulisation of 0.9% saline Intersurgical Cirrus 2 self sealing Jet Nebuliser

Conditions studied

• Respiratory Failure — all drugs for Respiratory Failure →
• Critical Illness — all drugs for Critical Illness →

Sponsor

NHS Greater Glasgow and Clyde — full company profile →

Who can join

Adults 18 to 80, any sex, with Respiratory Failure or Critical Illness. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Critically unwell patients in Intensive Care have a decreased ability to effectively clear secretions. High secretion load is a major risk factor in the failure of tracheal extubation failure and the requirement for reintubation. Extubation failure is a predictor of poor outcome independent of the severity of the underlying illness. Nebulisation of isotonic saline can be employed to manage secretions by reducing the secretion viscosity and facilitating clearance of respiratory sections during tracheal suction.

Standard jet nebulisers have been the mainstay of respiratory section management therapy in critical care since the early 1990s. A more recent development has been the vibrating mesh nebuliser. There is evidence of improved humidification and reduced water particle size and theoretically better transfer to the distal airways.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Prospective randomised unblinded comparison of sputum viscosity for three methods of saline nebulisation in mechanically ventilated patients: A pilot study protocol.
   Arnott A, Hart R, McQueen S, Watson M, et al · · 2023 · cited 3× · PMID 37590203 · DOI 10.1371/journal.pone.0290033
2. Prospective randomised unblinded comparison of sputum viscosity for three methods of saline nebulisation in mechanically ventilated patients: a study protocol
   Arnott A, Hart R, McQueen S, Watson M, et al · · 2022 · DOI 10.21203/rs.3.rs-2346909/v1