Who is sponsoring NCT05629000?

NCT05629000 is sponsored by Peking Union Medical College Hospital.

What drugs are being tested in NCT05629000?

Interventions in NCT05629000: Carotid revascularization, MRI-PWI, CTA, PET/MRI, Ultrasound.

What condition does NCT05629000 study?

NCT05629000 studies Carotid Artery Stenosis.

Is NCT05629000 still recruiting?

NCT05629000 is currently recruiting now. Last updated 29 November 2022.

Last reviewed 2022-11-29 · How we verify

NCT05629000: COAS-CAS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Optimization Strategy of Carotid Artery Stenosis

Recruiting now Last updated 29 November 2022

What this trial tests

trial testing Carotid revascularization in Carotid Artery Stenosis in 1,000 participants. Currently enrolling.

Timeline

1 January 2015

Primary endpoint
31 December 2025

31 December 2026

Quick facts

Lead sponsor	Peking Union Medical College Hospital
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	1,000
Start date	1 January 2015
Primary completion	31 December 2025
Estimated completion	31 December 2026
Sites	1 location across China

Drugs / interventions tested

Carotid revascularization
MRI-PWI
CTA
PET/MRI
Ultrasound

Conditions studied

Carotid Artery Stenosis — all drugs for Carotid Artery Stenosis →

Sponsor

Peking Union Medical College Hospital

Who can join

18 and older, any sex, with Carotid Artery Stenosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this observational study is to learn about how to utilize multiple evaluation techniques in carotid artery stenosis patients for optimizing assessment of diagnosis and treatment strategy. The main questions it aims to answer are: * Identify best strategy that use multi-modal MRI and CT to assess patients' cerebral lesions and perfusion. * Identify best strategy that use multi-modal MRI, PET-MRI ultrasound and CT to assess components and characters of patients' carotid plaques. Participants will accept imaging examination before and after surgery. And doctors will collect basic characteristics, imaging results and biological samples of patients for analysis.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Characterization of the proteome of stable and unstable carotid atherosclerotic plaques using data-independent acquisition mass spectrometry.
Lai Z, Wang C, Liu X, Sun H, et al · · 2024 · cited 8× · PMID 38454421 · DOI 10.1186/s12967-023-04723-1
Molecular landscape of atherosclerotic plaque progression: insights from proteomics, single-cell transcriptomics and genomics.
Wang C, Feng Y, Liu X, Sun H, et al · · 2025 · cited 5× · PMID 40307879 · DOI 10.1186/s12916-025-04058-2
Identification of histological carotid plaque vulnerability by CT angiography using perivascular adipose tissue radiomics signature.
Shu K, Chen J, Li K, Fan X, et al · · 2026 · PMID 41491918 · DOI 10.1186/s13244-025-02134-y

Verify or expand the search:

Other trials of Carotid revascularization

Trials testing the same drug.

NCT05800821 — Prediction of Cerebral Hyperperfusion Syndrome After Carotid Revascularization Using Deep Learning · recruiting

Other recruiting trials for Carotid Artery Stenosis

Currently open trials in the same condition.

NCT07370246 — CAS for Stenosis With High-risk Features for CEA · NA · recruiting
NCT07247864 — Balloon Guide Catheter Combined With Filter Protection for Carotid Artery Stenting · NA · recruiting
NCT06924593 — Study on the Trans-Carotid Artery Occlusion Shunt System · NA · recruiting
NCT07034157 — A Real-World Study on Ultrasound-Based Screening and Integrated Therapeutic Strategies for Patients With Concomitant Cor · recruiting
NCT06936176 — Prospective Trial of IVL for Calcified Carotid Lesions(CREATE Trial) · NA · recruiting

Other Peking Union Medical College Hospital trials

Trials by the same sponsor.

NCT07466251 — PCSK9 Inhibitor for Intracranial Atherosclerosis Related Acute Ischemic Stroke · Phase 4 · not yet recruiting
NCT06743321 — Speech-to-speech Voice-cloning Care (SVCC) to Improve ICU-acquired Anxiety for Critically Ill Patients · NA · not yet recruiting
NCT07590336 — 68Ga-NYM207 PET/CT Imaging in Hepatocellular Carcinoma · Phase 1, PHASE2 · not yet recruiting
NCT07515976 — Mapping of Genomic Structural Variations in Major Birth Defects · not yet recruiting
NCT07386756 — Early Precise Identification and Intervention Strategies for Individuals at High Risk of Prediabetes · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05629000 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Peking Union Medical College Hospital
Last refreshed: 29 November 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05629000.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing