Who is sponsoring NCT05628415?

NCT05628415 is sponsored by University Hospital, Basel, Switzerland.

What drugs are being tested in NCT05628415?

Interventions in NCT05628415: Non-powered AeonTM Endostapler (according to manufacturer medical device classification IIb), Echelon FLEX™ Powered plus Stapler (according to manufacturer medical device classification IIb).

What condition does NCT05628415 study?

NCT05628415 studies Postoperative Air Leak, Lung Resection.

Is NCT05628415 still recruiting?

NCT05628415 is currently completed. Last updated 21 February 2025.

Last reviewed 2025-02-21 · How we verify

NCT05628415: Stapler

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison Between the Non-powered AEON™ Endostapler and Echelon FLEX™ Powered Plus Stapler With Regards to the Closure of Lung Tissue After Lung Resection in the Presence of Severe Lung Emphysema

Completed NA Last updated 21 February 2025

What this trial tests

NA trial testing Non-powered AeonTM Endostapler (according to manufacturer medical device classification IIb) in Postoperative Air Leak in 19 participants. Completed in 20 February 2025.

Timeline

15 November 2022

Primary endpoint
20 February 2025

20 February 2025

Quick facts

Lead sponsor	University Hospital, Basel, Switzerland
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	19
Start date	15 November 2022
Primary completion	20 February 2025
Estimated completion	20 February 2025
Sites	1 location across Switzerland

Drugs / interventions tested

Non-powered AeonTM Endostapler (according to manufacturer medical device classification IIb)
Echelon FLEX™ Powered plus Stapler (according to manufacturer medical device classification IIb)

Conditions studied

Postoperative Air Leak — all drugs for Postoperative Air Leak →
Lung Resection — all drugs for Lung Resection →

Sponsor

University Hospital, Basel, Switzerland

Who can join

18 and older, any sex, with Postoperative Air Leak or Lung Resection. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Prolonged air leak is reported in up to 60 to 75% of patients after lung operation in the presence of severe lung emphysema. The effect of the non-powered AEONTM Endostapler as compared to the Echelon FlexTM Powered plus stapler on the volume and duration of air leak and on the time to chest drain removal after lung operation in the presence of severe lung emphysema will be investigated in a randomized, prospective, single-blinded clinical trial.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Efficacy of Non-Powered Stapler in Lung Volume Reduction Surgery of Severe Lung Emphysema: A Prospective Randomized Single-Blinded Monocentric Study.
Macharia-Nimietz EF, Mallaev M, Gecas P, Vujic J, et al · · 2026 · PMID 41787969 · DOI 10.1093/icvts/ivag071

Verify or expand the search:

Other University Hospital, Basel, Switzerland trials

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05628415 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Basel, Switzerland
Last refreshed: 21 February 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05628415.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing