NCT05623540 is a clinical trial of Bisphosphonates, Combinations in Diphosphonates, sponsored by National Defense Medical Center, Taiwan.

Who is sponsoring NCT05623540?

NCT05623540 is sponsored by National Defense Medical Center, Taiwan.

What drugs are being tested in NCT05623540?

Interventions in NCT05623540: Bisphosphonates, Combinations.

What condition does NCT05623540 study?

NCT05623540 studies Diphosphonates.

Is NCT05623540 still recruiting?

NCT05623540 is currently completed. Last updated 22 November 2022.

Last reviewed 2022-11-22 · How we verify

NCT05623540

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Bisphosphonates Use After Total Joint Arthroplasty

Completed Last updated 22 November 2022

What this trial tests

trial testing Bisphosphonates, Combinations in Diphosphonates in 27,405 participants. Completed in 2 November 2022.

Timeline

1 January 2000

Primary endpoint
31 December 2015

2 November 2022

Quick facts

Lead sponsor	National Defense Medical Center, Taiwan
Status	Completed
Study type	OBSERVATIONAL
Enrollment	27,405
Start date	1 January 2000
Primary completion	31 December 2015
Estimated completion	2 November 2022
Sites	1 location across Taiwan

Drugs / interventions tested

Bisphosphonates, Combinations — full drug profile →

Conditions studied

Diphosphonates — all drugs for Diphosphonates →

Sponsor

National Defense Medical Center, Taiwan

Who can join

40 and older, any sex, with Diphosphonates. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background Bisphosphonates has been associated with a decreased risk of revision total joint replacements because of its effects on decreased periprosthetic bone loss and prosthetic migration. However, the results in the early literature are inconsistent and the influence of bisphosphonates on associated complications and subsequent total joint arthroplasty (TJA) remains unknown. This study is to investigate the association between the use of bisphosphonates and risk of adverse outcomes after primary TJA. Materials and Methods This matched cohort study utilized National Health Insurance Research Database in Taiwan to identify patients who underwent primary TJA over a 15-year period (January 2000- December 2015 inclusive). Study participants were further categorized into two groups: bisphosphonates users and nonusers, using propensity score matching. The Kaplan-Meier curve analysis and adjusted hazard ratios (aHR) of revision surgery, adverse outcomes of primary surgery and undergoing subsequent TJA were calculated using Cox regression analysis.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Postoperative Bisphosphonates Use is Associated with Reduced Adverse Outcomes After Primary Total Joint Arthroplasty of Hip and Knee: A Nationwide Population-Based Cohort Study.
Shih JT, Tan TL, Shen PH, Yeh TT, et al · · 2024 · cited 7× · PMID 38492035 · DOI 10.1007/s00223-024-01192-6

Verify or expand the search:

Other National Defense Medical Center, Taiwan trials

Trials by the same sponsor.

NCT07373002 — Development and Evaluation of an Intelligent Parent-Infant Connection-Based Intervention to Strengthen Family Resilience · NA · not yet recruiting
NCT07488052 — Home-based Outpatient Multicenter Evaluation Using Electrocardiogram (HOME-ECG) · recruiting
NCT07307729 — AI-Enabled ECG Stratification and Timing of Potassium-Lowering Therapy in Patients With Hyperkalemia: A Target Trial Emu · NA · not yet recruiting
NCT07217236 — Proactive Risk Evaluation for Cardiac Implantable Electronic Device Strategy Using AI-ECG · NA · recruiting
NCT06887699 — The Impact of Artificial Intelligence Electrocardiography on Occlusion Myocardial Infarction Management Under the Value- · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05623540 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by National Defense Medical Center, Taiwan
Last refreshed: 22 November 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05623540.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing