NCT05623293

Ophthalmologic Outcomes in Patients With Carotid Artery Stenosis

Status unknown Last updated 21 November 2022

What this trial tests

trial testing eye - Optcial coherence tomography in Choroid Disease in 40 participants. Status unknown.

Timeline

1 January 2022

Primary endpoint
31 December 2023

31 December 2023

Quick facts

Lead sponsor	Universidade do Porto
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	40
Start date	1 January 2022
Primary completion	31 December 2023
Estimated completion	31 December 2023
Sites	1 location across Portugal

Drugs / interventions tested

• eye - Optcial coherence tomography

Conditions studied

• Choroid Disease — all drugs for Choroid Disease →
• Carotid Stenosis — all drugs for Carotid Stenosis →
• Carotid Atherosclerosis — all drugs for Carotid Atherosclerosis →
• Retinal Disease — all drugs for Retinal Disease →

Sponsor

Universidade do Porto — full company profile →

Who can join

18 and older, any sex, with Choroid Disease or Carotid Stenosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The retinal vessels have been shown to reflect vascular changes inherent to systemic pathologies, even when no ocular disease is identified. As such, the eye's vasculature is ableto serve as a window to the vascular health of the human body and a means of assessing systemic endothelial function. Optical coherence tomography angiography (OCTA) employs optical means to image all the retinal vascular layers and the choroid, providing an extremely detailed image of the microvascular network in a fast, reproducible and totally non-invasive way. As such, it is currently the best non-invasive way of having an image of human capillaries. Recently, OCTA has been used to study the retinal vessels' structure and function in several cardiovascular diseases. As an example of its predictive potential, reduced retinal microvascular density has been associated with the cardiovascular risk profile in patients admitted to the hospital for an acute coronary syndrome. Recent studies have also shown the retinal microvasculature density to be reduced in patients with carotid artery disease (CAD), namely carotid stenosis, and that endarterectomy increases retinal flow and vessel density.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Association of Radiomics and Pericarotid Adipose Tissue Characteristics with Systemic Inflammation in Patients Undergoing Carotid Endarterectomy.
   Santos-Teixeira D, Myrcha P, Trigo V, Ribeiro H, et al · · 2025 · PMID 41375644 · DOI 10.3390/jcm14238342