NCT05620810

Neuropsychiatric Symptoms in Spontaneous Intracerebral Hemorrhage Survivors

Status unknown Last updated 17 November 2022

What this trial tests

trial testing neuropsychiatric symptoms in Primary Disease or Condition Being Studied, or Focus of the Study in 120 participants. Status unknown.

Timeline

1 January 2023

Primary endpoint
31 December 2023

31 December 2023

Quick facts

Lead sponsor	National Taiwan University Hospital
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	120
Start date	1 January 2023
Primary completion	31 December 2023
Estimated completion	31 December 2023
Sites	1 location across Taiwan

Drugs / interventions tested

• neuropsychiatric symptoms

Conditions studied

• Primary Disease or Condition Being Studied, or Focus of the Study — all drugs for Primary Disease or Condition Being Studied, or Focus of the Study →

Sponsor

National Taiwan University Hospital

Who can join

20 and older, any sex, with Primary Disease or Condition Being Studied, or Focus of the Study. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Compared to the United Kingdom and the United States, Spontaneous non-traumatic intracerebral hemorrhage (ICH) is more common among people in Taiwan. The prevalence rate of ICH was 14.0% for people aged 36 years or older in Taiwan. Primary ICH originates from the spontaneous rupture of small vessels damaged by chronic hypertension or cerebral amyloid angiopathy (CAA). Emotional disturbances are frequent symptoms in stroke survivors and negatively impact on functional recovery, the patient's quality of life and are distressing for both the patients and their caregivers. Furthermore, the emotional disturbances are associated with impaired cognitive. However, these issues are often unnoticed and most of the studies had been performed in ischemic stroke survivors rather than in patients with ICH.

In this study, we will be recruited participants from National Taiwan University Hospital Bei-Hu branch and National Taiwan University Hospital. We aim to enroll respectively maximum number of 60 patients who had previous spontaneous ICH. Each participant will receive neuropsychiatric assessment, cognitive screening tests, domain-specific cognitive tests, a questionnaire for their quality of life and blood drawing for ApoE genotyping. The main aims of this study include (1) To investigate the prevalence of distinct neuropsychiatric symptoms in ICH survivors (2) To investigate the impact of non-cognitive neuropsychiatric issues on the cognitive functions and quality of life in ICH survivors. Our results may remind clinicians to pay more attention to the early diagnosis and effective management of neuropsychiatric symptoms to improve clinical outcomes.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.