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NCT05615610
Effects of Transcutaneous Electrical Nerve Stimulation on Cognitive Function and Upper Limb Motor Function in People With Chronic Stroke
NA trial testing tSCS in Chronic Stroke in 90 participants. Currently enrolling.
15 December 2025
Quick facts
| Lead sponsor | The Hong Kong Polytechnic University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 90 |
| Start date | 1 November 2023 |
| Primary completion | 15 December 2025 |
| Estimated completion | 15 December 2025 |
| Sites | 1 location across Hong Kong |
Drugs / interventions tested
- tSCS
- tVNS
- Control
Conditions studied
- Chronic Stroke — all drugs for Chronic Stroke →
Sponsor
The Hong Kong Polytechnic University
Who can join
Adults 50 to 80, any sex, with Chronic Stroke. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Upper limb impairment is present in more than 85% of people with stroke, which greatly affect the quality of life, social participation, and performance of daily activities of people with stroke. Previous study also revealed that 53.4% of people after stroke experienced cognitive impairment. Different cognitive domains might be affected following stroke, such as attention, memory, language, and orientation, and the problems with memory are often prominent. Yet, there is no effective treatment for the post-stroke cognitive impairment. Transcutaneous spinal cord stimulation (tSCS) and transcutaneous vagus nerve stimulation (tVNS) are simple and non-invasive treatment to improve upper limb motor function and cognitive function. However, no existing studies have explored on the effects of tSCS and tVNS on cognitive function in people with stroke. Therefore, the purpose of this study is to evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) on improving upper limb function and cognitive function in people with chronic stroke.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of transcutaneous electrical nerve stimulation on cognitive function and upper limb motor function in people with chronic stroke: a study protocol for a randomised controlled trial.
Chan NH, Ng SSM. · · 2025 · PMID 41397750 · DOI 10.1136/bmjopen-2025-108243
Verify or expand the search:
- PubMed search for NCT05615610
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of tSCS
Trials testing the same drug.
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- NCT07046143 — Study on the Efficacy of Non-invasive Spinal Cord Electrical Stimulation in Neuropathic Pain · NA · enrolling by invitation
Other recruiting trials for Chronic Stroke
Currently open trials in the same condition.
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- NCT07065292 — Plantar Sensation, Position Sense, and Weight-Bearing Asymmetry Related to Balance and Mobility Post-Stroke · recruiting
- NCT06286800 — Personalized Transcranial Direct Current Stimulation in Stroke Recovery · NA · recruiting
Other The Hong Kong Polytechnic University trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05615610 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Hong Kong Polytechnic University
- Last refreshed: 20 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05615610.
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