Who is sponsoring NCT05614440?

NCT05614440 is sponsored by Marmara University.

What drugs are being tested in NCT05614440?

Interventions in NCT05614440: Local anesthetic + tramadol hydrochloride, Only local anesthetic.

What condition does NCT05614440 study?

NCT05614440 studies Pain After the Surgical Extraction of Third Molars.

Is NCT05614440 still recruiting?

NCT05614440 is currently completed. Last updated 14 November 2022.

Last reviewed 2022-11-14 · How we verify

NCT05614440

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effects of Tramadol Combined With Local Anesthesia on Pain After the Surgical Extraction of Third Molars

Completed EARLY_PHASE1 Last updated 14 November 2022

What this trial tests

EARLY_PHASE1 trial testing Local anesthetic + tramadol hydrochloride in Pain After the Surgical Extraction of Third Molars in 60 participants. Completed in 1 January 2014.

Timeline

1 May 2012

Primary endpoint
1 November 2013

1 January 2014

Quick facts

Lead sponsor	Marmara University
Phase	EARLY_PHASE1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	60
Start date	1 May 2012
Primary completion	1 November 2013
Estimated completion	1 January 2014

Drugs / interventions tested

Local anesthetic + tramadol hydrochloride — full drug profile →
Only local anesthetic — full drug profile →

Conditions studied

Pain After the Surgical Extraction of Third Molars — all drugs for Pain After the Surgical Extraction of Third Molars →

Sponsor

Marmara University

Who can join

Adults 18 to 50, any sex, with Pain After the Surgical Extraction of Third Molars. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study was to assess the efficacy of local anesthetic and tramadol combinations in the prevention of pain after the surgical extraction of third molars.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Tramadol combined with local anesthesia for postoperative pain in third molar surgery.
Afat İM, Gönül O, Satılmış T. · · 2025 · PMID 41088090 · DOI 10.1186/s12903-025-07011-0

Verify or expand the search:

Other Marmara University trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05614440 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Marmara University
Last refreshed: 14 November 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05614440.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing