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NCT05613907

Can a Dedicated Chronic Limb-threatening Ischaemia (CLTI) Clinic Improve Patient Self-reported Quality of Life

Completed Results posted Last updated 14 February 2025
What this trial tests

trial testing CLTI Clinic in Chronic Limb Threatening Ischemia in 30 participants. Completed in 1 August 2024.

Timeline
17 November 2022
Primary endpoint
1 August 2024
1 August 2024

Quick facts

Lead sponsorThe Leeds Teaching Hospitals NHS Trust
StatusCompleted
Study typeOBSERVATIONAL
Enrollment30
Start date17 November 2022
Primary completion1 August 2024
Estimated completion1 August 2024
Sites1 location across United Kingdom

Drugs / interventions tested

Conditions studied

Sponsor

The Leeds Teaching Hospitals NHS Trust

Who can join

Adults 18 to 105, any sex, with Chronic Limb Threatening Ischemia. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

EuroQoL-5D Visual Acuity Scale (VAS) Score Primary · Baseline - 6-12 weeks - 1-year

The EuroQoL-5D is comprised of 2 parts, and the primary outcome involve scrutiny of the Visual Acuity Scale (VAS) represents a scale from 0 to 100 on which patients can report their own quality of life (0 the worst, 100 the best). The score is an integer and is measured again at 6-12 weeks, and again at 1-year post-initial assessment

GroupValue95% CI
CLTI Clinic Patients at Baseline47.55± 25.45
CLTI Patients at 6-12 Weeks69.15± 14.16
CLTI Patients at 1-year65.35± 15.86
EuroQoL-5D Movement Secondary · At baseline and 1-year

The EuroQol-5D is comprised of 2 parts, and the secondary outcomes involve scrutiny of the separate QoL domains that give rise to the 5D in the name, which are: mobility; self-care; usual activities; pain; anxiety and depression. Patients self-report their own experiences on a 5-point scale. We are comparing pre- and post-intervention levels of the above.

GroupValue95% CI
CLTI Clinic Patients at Baseline0
CLTI Patients at 1 Year2
CLTI Clinic Patients at Baseline2
CLTI Patients at 1 Year4
CLTI Clinic Patients at Baseline7
CLTI Patients at 1 Year6
CLTI Clinic Patients at Baseline11
CLTI Patients at 1 Year7
EuroQoL-5D Self Care Secondary · Baseline and 1-year

The EuroQol-5D is comprised of 2 parts, and the secondary outcomes involve scrutiny of the separate QoL domains that give rise to the 5D in the name, which are: mobility; self-care; usual activities; pain; anxiety and depression. Patients self-report their own experiences on a 5-point scale. We are comparing pre- and post-intervention levels of the above.

GroupValue95% CI
CLTI Clinic Patients at Baseline8
CLTI Patients at 1 Year9
CLTI Clinic Patients at Baseline4
CLTI Patients at 1 Year4
CLTI Clinic Patients at Baseline4
CLTI Patients at 1 Year4
CLTI Clinic Patients at Baseline4
CLTI Patients at 1 Year2
EuroQoL 5-D Usual Activities Secondary · Baseline and 1-year

The EuroQol-5D is comprised of 2 parts, and the secondary outcomes involve scrutiny of the separate QoL domains that give rise to the 5D in the name, which are: mobility; self-care; usual activities; pain; anxiety and depression. Patients self-report their own experiences on a 5-point scale. We are comparing pre- and post-intervention levels of the above.

GroupValue95% CI
CLTI Clinic Patients at Baseline2
CLTI Patients at 1 Year6
CLTI Clinic Patients at Baseline4
CLTI Patients at 1 Year5
CLTI Clinic Patients at Baseline6
CLTI Patients at 1 Year7
CLTI Clinic Patients at Baseline6
CLTI Patients at 1 Year0
EuroQoL 5-D Pain Secondary · Baseline and 1-year

The EuroQol-5D is comprised of 2 parts, and the secondary outcomes involve scrutiny of the separate QoL domains that give rise to the 5D in the name, which are: mobility; self-care; usual activities; pain; anxiety and depression. Patients self-report their own experiences on a 5-point scale. We are comparing pre- and post-intervention levels of the above.

GroupValue95% CI
CLTI Clinic Patients at Baseline1
CLTI Patients at 1 Year9
CLTI Clinic Patients at Baseline2
CLTI Patients at 1 Year4
CLTI Clinic Patients at Baseline6
CLTI Patients at 1 Year3
CLTI Clinic Patients at Baseline10
CLTI Patients at 1 Year3
EuroQoL 5-D Anxiety and/or Depression Secondary · Baseline and 1-year

The EuroQol-5D is comprised of 2 parts, and the secondary outcomes involve scrutiny of the separate QoL domains that give rise to the 5D in the name, which are: mobility; self-care; usual activities; pain; anxiety and depression. Patients self-report their own experiences on a 5-point scale. We are comparing pre- and post-intervention levels of the above.

GroupValue95% CI
CLTI Clinic Patients at Baseline5
CLTI Patients at 1 Year10
CLTI Clinic Patients at Baseline6
CLTI Patients at 1 Year1
CLTI Clinic Patients at Baseline6
CLTI Patients at 1 Year9
CLTI Clinic Patients at Baseline3
CLTI Patients at 1 Year0
Revascularised EuroQoL 5-D VAS Score Secondary · Baseline - 6-12 weeks - 1-year

The EuroQoL-5D is comprised of 2 parts, and the primary outcome involve scrutiny of the Visual Acuity Scale (VAS) represents a scale from 0 to 100 on which patients can report their own quality of life (0 the worst, 100 the best). The score is an integer and is measured again at 6-12 weeks, and again at 1-year post-initial assessment. This sub-group analysis is of patients who underwent revascularisation procedures.

GroupValue95% CI
CLTI Clinic Patients at Baseline39.85± 27.525
CLTI Patients at 6-12 Weeks66.69± 15.206
CLTI Patients at 1-year67.46± 16.008
Non-operative EuroQoL 5-D VAS Score Secondary · Baseline - 6-12 weeks - 1-year

The EuroQoL-5D is comprised of 2 parts, and the primary outcome involve scrutiny of the Visual Acuity Scale (VAS) represents a scale from 0 to 100 on which patients can report their own quality of life (0 the worst, 100 the best). The score is an integer and is measured again at 6-12 weeks, and again at 1-year post-initial assessment. This sub-group analysis is of patients who did not undergo revascularisation procedures.

GroupValue95% CI
CLTI Clinic Patients at Baseline58.83± 12.954
CLTI Patients at 6-12 Weeks73.71± 11.615
CLTI Patients at 1-year61.43± 15.999

Sponsor's own description

CLTI is the most severe form of peripheral arterial disease. Patients with the condition require investigation and management (typically in the form of revascularisation surgery) to salvage the limb. Traditionally, patients with the condition are admitted into hospital for their management, but with the advent of regional vascular networks, this is becoming increasingly difficult. Recently, the Vascular Society of Great Britain and Ireland have advocated for the use of dedicated CLTI clinics to overcome this problem. Whilst there is burgeoning evidence for their clinical benefit, there is a lack of patient reported outcomes to measure their impact on patient selr-reported quality of life. We would like to determine if this service benefits its users as much as the clinical outcomes suggest it does.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Chronic Limb Threatening Ischemia

Currently open trials in the same condition.

Other The Leeds Teaching Hospitals NHS Trust trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05613907.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing