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NCT05613179
Brain Effect Mechanism of Lever Positioning Manipulation on LDH Analgesia Based on Multimodal MRI
NA trial testing Group1 (lever positioning manipulation) in Lumbar Disc Herniation in 90 participants. Completed in 1 May 2025.
1 May 2025
Quick facts
| Lead sponsor | The Third Affiliated hospital of Zhejiang Chinese Medical University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 90 |
| Start date | 1 September 2021 |
| Primary completion | 1 May 2025 |
| Estimated completion | 1 May 2025 |
| Sites | 1 location across China |
Drugs / interventions tested
- Group1 (lever positioning manipulation)
- Group2 (placebo group)
Conditions studied
- Lumbar Disc Herniation — all drugs for Lumbar Disc Herniation →
- Multimodal Brain Function — all drugs for Multimodal Brain Function →
- Analgesia Mechanism — all drugs for Analgesia Mechanism →
- Lever Positioning Manipulation — all drugs for Lever Positioning Manipulation →
Sponsor
The Third Affiliated hospital of Zhejiang Chinese Medical University
Who can join
Adults 18 to 65, any sex, with Lumbar Disc Herniation or Multimodal Brain Function. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In order to further investigate the key brain targets and central response mechanism characteristics of analgesia, the dominant disease of LDH was taken as the object of this study, which was divided into operation group, comfort group and healthy subjects group. Firstly, DTI probabilistic tracking method was used to detect the changes of the brain white matter in each group. Then, the low-frequency amplitude (mfalff) and local consistency (ReHo) of each group were compared by fMRI scanning imaging technology, and the features of local brain functional connectivity (FC) of pain matrix related brain regions as seed points were analyzed. Finally, MRS Technique was used to detect the brain signals of related metabolites glutamic acid (Glu) and 1-aminobutyric acid (GABA), so as to elucidate the network regulation of lever-positioning operation on the analgesic brain effect of LDH and the biochemical mechanism of central nervous system. This multimodal MRI technique provides biological basis for the clinical application of lever localization in LDH.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Remodeling of the ventral attention network-default mode network as potential neural correlates of anxiety in lumbar disc herniation patients treated with lever positioning manipulation: a resting-state fMRI study.
Zhou XC, Wu S, Wang KZ, Chen LH, et al · · 2026 · PMID 41840560 · DOI 10.1186/s12906-026-05343-0 -
Brain effect mechanism of lever positioning manipulation on LDH analgesia based on multimodal MRI: a study protocol.
Zhou XC, Chen LH, Wu S, Wang KZ, et al · · 2024 · PMID 38915038 · DOI 10.1186/s12906-024-04549-4
Verify or expand the search:
- PubMed search for NCT05613179
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05613179 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Third Affiliated hospital of Zhejiang Chinese Medical University
- Last refreshed: 15 June 2025
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