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Kinetics of Methemoglobin Concentration in Healthy Subjects Exposed to High Dose Inhaled Nitric Oxide
The goal of this clinical trial is to learn about the kinetic of methemoglobin in healthy subjects breathing high dose inhaled nitric oxide. The main questions it aims to answer are: * What are the kinetics of methemoglobin formation at a maximum of 300 parts per million of nitric oxide and oxygen * What are the kinetics of methemoglobin reduction after nitric oxide discontinuation Participants will be exposed to intermittent high dose inhaled nitric oxide at a maximum of 300 parts per million while being continuously monitored.
Details
| Lead sponsor | Massachusetts General Hospital |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | ACTIVE_NOT_RECRUITING |
| Enrolment | 10 |
| Start date | 2023-10-16 |
| Completion | 2027-12 |
Conditions
- Healthy Subjects
Interventions
- Inhaled Nitric Oxide
Primary outcomes
- Methemoglobin kinetics — 7 days
Levels of methemoglobin formation and reduction during and after exposure to high dose inhaled nitric oxide
Countries
United States