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NCT05611437: REVEAL
Ultrafast Ultrasonographic Oro-laryngeal Measurement in Critically Ill Patients During Weaning From Mechanical Ventilation
trial testing Ultrafast ultrasonography in Laryngeal Edema in 150 participants. Status unknown.
31 August 2024
Quick facts
| Lead sponsor | Groupe Hospitalier du Havre |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 150 |
| Start date | 1 December 2022 |
| Primary completion | 31 August 2024 |
| Estimated completion | 31 August 2024 |
| Sites | 1 location across France |
Drugs / interventions tested
- Ultrafast ultrasonography
Conditions studied
- Laryngeal Edema — all drugs for Laryngeal Edema →
Sponsor
Groupe Hospitalier du Havre
Who can join
18 and older, any sex, with Laryngeal Edema. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In ICU, ventilatory weaning failure is common, accounting for up to 25% of extubations. These failures are largely due to swallowing disorders and laryngeal edema. Edema prevalence in ICU varies between 4 and 37%. Post-extubation stridor is a clinical sign of upper airway obstruction and may require urgent reintubation, which is associated with increased patient length of stay, morbidity and mortality. Identifying patients at risk is critical, and the need for reliable tools to predict the occurence of laryngeal edema is still relevant.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Oropharyngeal ultrafast ultrasound measurements in mechanically ventilated critically ill patients do not identify post-extubation stridor.
Machefert M, Prieur G, Díaz López C, Dubois C, et al · · 2025 · cited 1× · PMID 40999537 · DOI 10.1186/s13054-025-05659-2
Verify or expand the search:
- PubMed search for NCT05611437
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Laryngeal Edema
Currently open trials in the same condition.
- NCT06670521 — Corticosteroids for Post-Extubation Dysphagia · Phase 2 · recruiting
Other Groupe Hospitalier du Havre trials
Trials by the same sponsor.
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- NCT06994689 — Clinimetric Properties of Muscle Mass and Stiffness Measurements of the Quadriceps in Patients With COPD · recruiting
- NCT06249412 — The Importance of Positive Expiratory Pressure Associated With the In-exsufflator in ALS Patients · NA · recruiting
- NCT06772701 — Validation of the French Version of the Edinburgh Postnatal Depression Scale (EPDS) Postnatally in the Father · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05611437 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Groupe Hospitalier du Havre
- Last refreshed: 24 February 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05611437.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing