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Supplementation of Autologous Fat Grafts with Curcumin Preconditioned Adipose-Derived Stem Cells in the Treatment of Facial Contour Deformities
The aim of this study is to evaluate the comparison of therapeutic potential of curcumin preconditioned adipose derived stem cells (ASCs) enrichment fat grafting, naïve ASCs enrichment fat grafting and conventional fat grafting to correct facial contour deformities that cause aesthetic complications in patients.
Details
| Lead sponsor | University of the Punjab |
|---|---|
| Phase | Phase 1 |
| Status | RECRUITING |
| Enrolment | 24 |
| Start date | 2020-11-20 |
| Completion | 2025-12 |
Conditions
- Romberg Disease
- Craniofacial Microsomia
- Burn Scar
- Post-Traumatic Scar (Disorder)
Interventions
- Cultured ASCs enrichment fat grafting
- Curcumin-preconditioned ASCs enrichment fat grafting
- Conventional fat grafting
Primary outcomes
- Volumetric change in facial tissue by ultrasonography — 9 months
Volumetric evaluation of treated area will be done by measuring the thickness of subcutaneous tissue (in millimeters) by using baseline B mode ultrasound device. Volumetric evaluation of treated area will be done by measuring the thickness of subcutaneous tissue (in millimeters) before transplantation, 1 week after transplantation then after 3, 6 and 9 months by using baseline B mode ultrasound device.
Countries
Pakistan