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NCT05609981
Optimising Medication With Focus on Deprescribing in Frail Older People With Multidose Drug Dispensing Systems
NA trial testing Clinical medication review focused on deprescribing in Deprescriptions in 318 participants. Completed in 27 June 2025.
21 February 2025
Quick facts
| Lead sponsor | SIR Institute for Pharmacy Practice and Policy |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | health services research |
| Enrollment | 318 |
| Start date | 10 November 2022 |
| Primary completion | 21 February 2025 |
| Estimated completion | 27 June 2025 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Clinical medication review focused on deprescribing
Conditions studied
- Deprescriptions — all drugs for Deprescriptions →
- Polypharmacy — all drugs for Polypharmacy →
- Primary Health Care — all drugs for Primary Health Care →
- Community Pharmacy Services — all drugs for Community Pharmacy Services →
Sponsor
SIR Institute for Pharmacy Practice and Policy
Who can join
75 and older, any sex, with Deprescriptions or Polypharmacy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Overuse is common in frail older people with polypharmacy, especially in frail older users of multidose drug dispensing (MDD) systems. In this study, we will investigate the effect of a clinical medication review (CMR) with integration of deprescribing (toolbox) on the number of ceased and dose lowered medications (persistent after 6 months) compared to usual care in older users of MDD systems with hyperpolypharmacy. We will perform a controlled cluster-randomized trial in 38 community pharmacies. Per pharmacy, 10 older patients (\>= 75) with hyperpolyfpharmacy (\>10 medicines in use) with a MDD will be included. Pharmacists will receive training to perform the intervention, a 5-step CMR with a deprescribing toolbox (including deprescribing protocols): 1) patient interview; 2) pharmacotherapeutic analysis; 3) pharmacist and GP discuss actions; 4) actions are discussed with patient; 5) (two)weekly follow-up.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05609981
- Europe PMC full search
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Related trials
Other recruiting trials for Deprescriptions
Currently open trials in the same condition.
- NCT05875623 — Impact of Medications Review on Potentially Inappropriate Medications and Clinical Outcomes Among Hospitalized Older Adu · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05609981 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by SIR Institute for Pharmacy Practice and Policy
- Last refreshed: 31 July 2025
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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing