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NCT05609526
Inspiratory and Calf Muscles Training in Patients With Leg Lymphedema
NA trial testing Compression Therapy in Lymphedema of Leg in 45 participants. Status unknown.
10 June 2023
Quick facts
| Lead sponsor | Istanbul University - Cerrahpasa |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 45 |
| Start date | 14 November 2022 |
| Primary completion | 10 June 2023 |
| Estimated completion | 12 September 2023 |
Drugs / interventions tested
- Compression Therapy
- Inspiratory muscle training
- Calf muscle exercise training
Conditions studied
- Lymphedema of Leg — all drugs for Lymphedema of Leg →
- Lymphedema — all drugs for Lymphedema →
- Exercise — all drugs for Exercise →
Sponsor
Istanbul University - Cerrahpasa
Who can join
Adults 18 to 75, any sex, with Lymphedema of Leg or Lymphedema. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Lymphedema results in the accumulation of protein-rich fluid in the subcutaneous tissue as a result of the failure of the lymphatic system, which returns water and protein in the interstitial spaces to the bloodstream. The aim of its treatment is to return this fluid accumulated in the interstitial space to the venous system. Early diagnosis and subsequent treatment of lymphedema, which is a chronic and progressive problem, is important to improve symptoms and prevent complications. Exercises recommended by specialist physiotherapists increase lymph flow and improve protein resorption. Exercises applied with compression bandages or compression garments provide significant improvement in patients with lymphedema. The aim of this study is to provide inspiratory muscle training and leg compression therapy together with compression therapy in patients with lower extremity lymphedema. To evaluate the effectiveness of these exercises on the patient's extremity volume and fullness, tissue water content, edema status, walking capacity, functionality and quality of life by comparing the effectiveness of muscle exercise training. In addition, researchers aim to determine the more effective exercise method for these patients.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
The effect of muscles in the treatment of lower limb lymphedema: respiratory muscles or leg muscles?
Akgul A, Mazi İ, Aydin G, Yavuz M, et al · · 2025 · cited 1× · PMID 40214771 · DOI 10.1007/s00520-025-09436-3 -
The effect of exercise in patients with lower limb lymphedema: a systematic review.
Wittenkamp MC, Christensen J, Vinther A, Juhl CB. · · 2025 · cited 1× · PMID 40165003 · DOI 10.2340/1651-226x.2025.42560
Verify or expand the search:
- PubMed search for NCT05609526
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Compression Therapy
Trials testing the same drug.
- NCT05383469 — Efficacy of Active Versus Passive Methods in Chronic Venous Insufficiency · NA · completed
- NCT03873272 — The CONTRoL Trial: Cryotherapy vs. cOmpression Neuropathy TRiaL · NA · completed
- NCT03755180 — Exercise Training in Venous Insufficiency · NA · completed
- NCT03384758 — Evaluation of Compression Therapy in Patients With Mild to Moderate PAD or Diabetes Mellitus · NA · completed
Other recruiting trials for Lymphedema of Leg
Currently open trials in the same condition.
- NCT06082349 — The N-LVA Study: RCT Comparing LVA vs. Sham Surgery in Cancer-related Lymphedema · NA · recruiting
Other Istanbul University - Cerrahpasa trials
Trials by the same sponsor.
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- NCT07378449 — The Effect of Hand Exercise Hoops on Labour Pain · NA · not yet recruiting
- NCT07293000 — Evaluating Two Nursing Interventions to Prevent Urinary Retention After Spinal Anesthesia · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05609526 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Istanbul University - Cerrahpasa
- Last refreshed: 18 November 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05609526.
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