NCT05605444 is a NA clinical trial of Single bout of exercise in Osteoarthritis, Knee, sponsored by Taif University.

Who is sponsoring NCT05605444?

NCT05605444 is sponsored by Taif University.

What drugs are being tested in NCT05605444?

Interventions in NCT05605444: Single bout of exercise.

What condition does NCT05605444 study?

NCT05605444 studies Osteoarthritis, Knee.

Is NCT05605444 still recruiting?

NCT05605444 is currently completed. Last updated 28 August 2025.

Last reviewed 2025-08-28 · How we verify

NCT05605444

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of an Acute Bout of Exercise on Pain Sensitivity and Clinical Pain in Adults With Knee Osteoarthritis

Completed NA Last updated 28 August 2025

What this trial tests

NA trial testing Single bout of exercise in Osteoarthritis, Knee in 90 participants. Completed in 20 May 2023.

Timeline

15 November 2022

Primary endpoint
25 April 2023

20 May 2023

Quick facts

Lead sponsor	Taif University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	90
Start date	15 November 2022
Primary completion	25 April 2023
Estimated completion	20 May 2023
Sites	1 location across Saudi Arabia

Drugs / interventions tested

Single bout of exercise

Conditions studied

Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →

Sponsor

Taif University

Who can join

Adults 18 to 65, any sex, with Osteoarthritis, Knee. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this interventional study is to investigate the effectiveness of an acute bout of exercises on pain sensitivity and clinical pain among adults with knee osteoarthritis. The following question will be answered in this research Q1: Is acute bout of exercise effective in reducing pain sensitivity and intensity among adult with knee osteoarthritis? Participants who agree to participate and sign the informed consent will be randomised to one of three groups: Group 1: Isometric exercise with neutral language and no verbal suggestion consisting of 1 rep of wall squat, 3 min or to volitional fatigue at 100° knee angle;(n=30). Group 2: Isometric exercise with neutral language and no verbal suggestion consisting of 3 reps of wall squat, 3 min or to volitional fatigue at 100°degree knee angle, 30 sec rest between rep, ;(n=30). Group 3 (Control group): true control (do nothing);(n=30).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Efficacy of an acute bout of isometric wall squat exercise on pain sensitivity and clinical pain intensity in adults with knee osteoarthritis: a randomised controlled trial in outpatient physiotherapy clinics in Saudi Arabia.
Zabarmawi J, Miller CT, Owen PJ, Mundell NL, et al · · 2025 · PMID 41381113 · DOI 10.1136/bmjopen-2025-103756

Verify or expand the search:

Other trials of Single bout of exercise

Trials testing the same drug.

NCT05779748 — The Effect of an Acute Bout of Exercise on Pain Sensitivity and Clinical Pain in Adults With Chronic Low Back Pain · NA · completed

Other recruiting trials for Osteoarthritis, Knee

Currently open trials in the same condition.

NCT07509307 — AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee · Phase 3 · recruiting
NCT06488144 — Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans · Phase 3 · recruiting
NCT07386561 — Virtual Reality Therapy and Non-Sleep Deep Rest Relaxation After Joint Arthroplasty · NA · active not recruiting
NCT07514598 — Effect of J-Shaped Incision After Total Knee Arthroplasty (J-TKA) · NA · active not recruiting
NCT07058623 — Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement · NA · recruiting

Other Taif University trials

Trials by the same sponsor.

NCT06963658 — Acute Effect of Isometric Excercise on Pain Sensitivity in Adults With Chronic Low Back Pain · NA · recruiting
NCT06430255 — Effects of Global Postural Re-education Versus Laser-guided Exercise in Non-specific Chronic Low Back Pain · NA · not yet recruiting
NCT06301490 — The Effect of Myofascial Release in Patients With Subacromial Impingement Syndrome · NA · completed
NCT05771220 — Radial Extracorporeal Shockwave Therapy Combined With Evidence-Based Physical Therapy for Adhesive Capsulitis · NA · completed
NCT05779748 — The Effect of an Acute Bout of Exercise on Pain Sensitivity and Clinical Pain in Adults With Chronic Low Back Pain · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05605444 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Taif University
Last refreshed: 28 August 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05605444.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing