NCT05605431

Predictors of OSA in Patients With COPD

Completed Last updated 27 June 2023

What this trial tests

trial testing Polysomnography in OSA in 60 participants. Completed in 30 November 2020.

Timeline

1 March 2020

Primary endpoint
30 November 2020

30 November 2020

Quick facts

Lead sponsor	Cairo University
Status	Completed
Study type	OBSERVATIONAL
Enrollment	60
Start date	1 March 2020
Primary completion	30 November 2020
Estimated completion	30 November 2020
Sites	1 location across Egypt

Drugs / interventions tested

• Polysomnography

Conditions studied

• OSA — all drugs for OSA →
• COPD — all drugs for COPD →

Sponsor

Cairo University

Who can join

Adults 25 to 76, any sex, with OSA or COPD. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea(OSA) are common disorders ,the co-existence of both conditions is called overlap syndrome Smoking , obesity , airway resistance and inflammation are considered risk factors for both conditions ,interestingly either COPD and OSA are associated with increased cardiovascular complications with further increased risk in overlap syndrome Multiple theories could explain that one disorder can predispose or exaggerate the other. For example, in COPD cigarette smoking and inhaled steroids are linked to myopathy of upper airway dilator muscles. Moreover in core-pulmonale redistribution of edema fluid in supine position during sleep can also contribute to or exacerbate OSA .

On the other hand , OSA patients might smoke frequently and more heavily to compensate for excessive daytime sleepiness and to help them to lose weight , which results in exaggerated airway inflammation and exacerbate COPD. Rationale of the study was to assess the prevalence and predictors of OSA among patients with stable COPD.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.