NCT05601661 is a NA clinical trial of Active VNS in Cervical Spinal Cord Injury, sponsored by The University of Texas Health Science Center, Houston.

Who is sponsoring NCT05601661?

NCT05601661 is sponsored by The University of Texas Health Science Center, Houston.

What drugs are being tested in NCT05601661?

Interventions in NCT05601661: Active VNS, Sham VNS, Arm rehabilitation.

What condition does NCT05601661 study?

NCT05601661 studies Cervical Spinal Cord Injury.

Is NCT05601661 still recruiting?

NCT05601661 is currently completed. Last updated 28 October 2025.

Last reviewed 2025-10-28 · How we verify

NCT05601661

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Safety and Feasibility of Paired Vagus Nerve Stimulation With Rehabilitation for Improving Upper Extremity Function in People With Cervical Spinal Cord Injury

Completed NA Last updated 28 October 2025

What this trial tests

NA trial testing Active VNS in Cervical Spinal Cord Injury in 6 participants. Completed in 16 August 2025.

Timeline

15 June 2023

Primary endpoint
16 August 2025

16 August 2025

Quick facts

Lead sponsor	The University of Texas Health Science Center, Houston
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	6
Start date	15 June 2023
Primary completion	16 August 2025
Estimated completion	16 August 2025
Sites	1 location across United States

Drugs / interventions tested

Active VNS
Sham VNS
Arm rehabilitation

Conditions studied

Cervical Spinal Cord Injury — all drugs for Cervical Spinal Cord Injury →

Sponsor

The University of Texas Health Science Center, Houston

Who can join

18 and older, any sex, with Cervical Spinal Cord Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to determine the safety and feasibility of pairing vagus nerve stimulation (VNS) with rehabilitation and to determine the efficacy of pairing VNS with rehabilitation.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Neurorehabilitation with vagus nerve stimulation: a systematic review.
Korupolu R, Miller A, Park A, Yozbatiran N. · · 2024 · cited 11× · PMID 38872818 · DOI 10.3389/fneur.2024.1390217
Safety and feasibility of paired vagus nerve stimulation with rehabilitation for improving upper extremity function in people with cervical spinal cord injury: study protocol for a pilot randomized controlled trial.
Yozbatiran N, Francisco GE, Korupolu R. · · 2024 · PMID 39610700 · DOI 10.3389/fneur.2024.1465764

Verify or expand the search:

Other recruiting trials for Cervical Spinal Cord Injury

Currently open trials in the same condition.

NCT06701422 — Targeting Cervical Epidural Spinal Cord Stimulation for Functional Recovery · NA · recruiting
NCT06700304 — CAN-PRIME: Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices · NA · recruiting
NCT06225245 — Augmenting Rehabilitation Outcomes and Functional Neuroplasticity Using Epidural Stimulation of Cervical Spinal Cord · NA · recruiting
NCT06511934 — Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01) · NA · recruiting
NCT06440538 — Rebuilding Inter-limb Transfer in Cervical SCI · EARLY_PHASE1 · active not recruiting

Other The University of Texas Health Science Center, Houston trials

Trials by the same sponsor.

NCT04200729 — Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-cente · Phase 4 · not yet recruiting
NCT07225062 — Improving HIV Prevention and Substance Use Post-Sexual Assault Services · NA · not yet recruiting
NCT07396974 — Increasing Treatment Access in Trauma Exposed Children: Developing an Adapted Step One Intervention (RCT) · NA · not yet recruiting
NCT07170163 — Navigating the Transition to Adulthood: A Dual Language Mobile App for Latino Youth With ASD and Their Families · NA · not yet recruiting
NCT06915441 — Lipid Infusions to Optimize Nutrition Trial · Phase 2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05601661 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The University of Texas Health Science Center, Houston
Last refreshed: 28 October 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05601661.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing