NCT05601544

The Effects of Contact Lenses With UV/HEV-Filter on Visual Function

Completed NA Results posted Last updated 27 April 2025

What this trial tests

NA trial testing ACUVUE OASYS 1-Day in Visual Acuity in 145 participants. Completed in 17 November 2023.

Timeline

9 December 2022

Primary endpoint
17 November 2023

17 November 2023

Quick facts

Lead sponsor	Johnson & Johnson Vision Care, Inc.
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	145
Start date	9 December 2022
Primary completion	17 November 2023
Estimated completion	17 November 2023
Sites	1 location across United States

Drugs / interventions tested

• ACUVUE OASYS 1-Day
• ACUVUE OASYS MAX 1-Day
• ACUVUE OASYS Multifocal
• ACUVUE OASYS MAX 1-Day Multifocal
• ACUVUE OASYS 1-Day for Astigmatism
• senofilcon A based contact lens (toric) with new UV/HEV filter

Conditions studied

• Visual Acuity — all drugs for Visual Acuity →

Sponsor

Johnson & Johnson Vision Care, Inc. — full company profile →

Who can join

Adults 18 to 70, any sex, with Visual Acuity. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Visual Range at Phase 1 Primary · Approximately 15 minutes post lens fitting

Visual range is defined as the log relative energy of simulated haze needed to obscure an otherwise high contrast grating target. Better visual range is indicated by a higher log-relative energy (LRE) of simulated haze (more haze) to obscure an otherwise highly visible target.

Group	Value	95% CI
Senofilcon A (Test) Sphere Strata - Phase 1	3.232	± 0.1658
Senofilcon A (Control) Sphere Strata - Phase 1	3.049	± 0.2101
Senofilcon A (Test) Multifocal Strata - Phase 1	3.287	± 0.1824
Senofilcon A (Control) Multifocal Strata - Phase 1	3.167	± 0.1072

Visual Range at Phase 2 Primary · Approximately 15 minutes post lens fitting

Visual range is defined as the log relative energy of simulated haze needed to obscure an otherwise high contrast grating target. Better visual range is indicated by a higher log-relative energy (LRE) of simulated haze (more haze) to obscure an otherwise highly visible target.

Group	Value	95% CI
Senofilcon A (Test) Sphere Strata - Phase 2	3.377	± 0.1489
Senofilcon A (Control) Sphere Strata - Phase 2	3.156	± 0.1181
Senofilcon A (Test) Multifocal Strata - Phase 2	3.181	± 0.1649
Senofilcon A (Control) Multifocal Strata - Phase 2	3.020	± 0.1412

Motion Detection at Phase 1 Primary · Approximately 15 minutes post lens fitting

Motion detection is defined as the distance needed (in mm) to determine that a test light has moved from a standard position. Better motion detection is indicated by a smaller distance needed to detect that movement has occurred.

Group	Value	95% CI
Senofilcon A (Test) Sphere Strata - Phase 1	1.725	± 1.3575
Senofilcon A (Control) Sphere Strata - Phase 1	2.881	± 1.9824
Senofilcon A (Test) Multifocal Strata - Phase 1	3.229	± 2.3248
Senofilcon A (Control) Multifocal Strata - Phase 1	2.716	± 3.1286

Brightness Perception at Phase 1 Primary · Approximately 15 minutes post lens fitting

Brightness perception is defined as the log- relative energy needed to match a standard stimulus to a natural scene, across 10 different projected scenes. The perception of brighter image is indicated by a higher log-relative energy (LRE) needed to match the initially dim standard to the target.

Group	Value	95% CI
Senofilcon A (Test) Sphere Strata - Phase 1	1.109	± 0.0909
Senofilcon A (Control) Sphere Strata - Phase 1	1.081	± 0.1494
Senofilcon A (Test) Multifocal Strata - Phase 1	1.101	± 0.1388
Senofilcon A (Control) Multifocal Strata - Phase 1	1.041	± 0.2222

Motion Detection at Phase 2 Secondary · Approximately 15 minutes post lens fitting

Motion detection is defined as the distance needed (in mm) to determine that a test light has moved from a standard position. Better motion detection is indicated by a smaller distance needed to detect that movement has occurred.

Group	Value	95% CI
Senofilcon A (Test) Sphere Strata - Phase 2	3.894	± 2.6800
Senofilcon A (Control) Sphere Strata - Phase 2	4.288	± 2.9575
Senofilcon A (Test) Multifocal Strata - Phase 2	3.499	± 2.4146
Senofilcon A (Control) Multifocal Strata - Phase 2	3.3376	± 2.3750

Brightness Perception at Phase 2 Secondary · Approximately 15 minutes post lens fitting

Brightness perception is defined as the log- relative energy needed to match a standard stimulus to a natural scene, across 10 different projected scenes. The perception of brighter image is indicated by a higher log-relative energy (LRE) needed to match the initially dim standard to the target.

Group	Value	95% CI
Senofilcon A (Test) Sphere Strata - Phase 2	1.356	± 0.0670
Senofilcon A (Control) Sphere Strata - Phase 2	1.222	± 0.0615
Senofilcon A (Test) Multifocal Strata - Phase 2	1.360	± 0.0832
Senofilcon A (Control) Multifocal Strata - Phase 2	1.219	± 0.0843

Sponsor's own description

This is a 2-phase, single-site, non-dispensing, randomized, controlled, double-masked, 2x2 crossover study to objectively measure potential benefits of a new UV/HEV filter using psychophysical testing techniques.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. The effects of a HEV-filtering contact lens on the brightness of natural images.
   Hammond BR, Buch JR, Martin P, Shamp W, et al · · 2025 · cited 2× · PMID 41159572 · DOI 10.1111/opo.70035