NCT05600374 (Boss-Stroke) is a NA clinical trial of Bossdevice in Ischemic Stroke, Acute, sponsored by University Hospital Tuebingen.

Who is sponsoring NCT05600374?

NCT05600374 is sponsored by University Hospital Tuebingen.

What drugs are being tested in NCT05600374?

Interventions in NCT05600374: Bossdevice.

What condition does NCT05600374 study?

NCT05600374 studies Ischemic Stroke, Acute.

Is NCT05600374 still recruiting?

NCT05600374 is currently recruiting now. Last updated 22 November 2023.

Last reviewed 2023-11-22 · How we verify

NCT05600374: Boss-Stroke

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Brain-Oscillation-Synchronized Stimulation to Enhance Motor Recovery in Early Subacute Stroke

Recruiting now NA Last updated 22 November 2023

What this trial tests

NA trial testing Bossdevice in Ischemic Stroke, Acute in 144 participants. Currently enrolling.

Timeline

6 February 2023

Primary endpoint
31 May 2025

28 February 2028

Quick facts

Lead sponsor	University Hospital Tuebingen
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	144
Start date	6 February 2023
Primary completion	31 May 2025
Estimated completion	28 February 2028
Sites	7 locations across Germany

Drugs / interventions tested

Bossdevice

Conditions studied

Ischemic Stroke, Acute — all drugs for Ischemic Stroke, Acute →

Sponsor

University Hospital Tuebingen

Who can join

18 and older, any sex, with Ischemic Stroke, Acute. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

We will investigate the therapeutic efficacy of EEG-synchronized noninvasive repetitive transcranial magnetic stimulation (rTMS) in the early subacute phase after ischemic stroke to improve upper limb motor rehabilitation. We hypothesize that synchronization of rTMS with the phase of the ongoing sensorimotor oscillation indicating high corticospinal excitability leads to significantly stronger improvement of paretic upper limb motor function than the same rTMS protocol non-synchronized to the ongoing sensorimotor oscillation or sham stimulation.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Brain-oscillation-synchronized stimulation to enhance motor recovery in early subacute stroke: a randomized controlled double-blind three- arm parallel-group exploratory trial comparing personalized, non- personalized and sham repetitive transcranial magnetic stimulation (Acronym
Lieb A, Zrenner B, Zrenner C, Kozák G, et al · · 2023 · cited 12× · PMID 37231390 · DOI 10.1186/s12883-023-03235-1
Brain state-dependent repetitive transcranial magnetic stimulation for motor stroke rehabilitation: a proof of concept randomized controlled trial.
Mahmoud W, Baur D, Zrenner B, Brancaccio A, et al · · 2024 · cited 9× · PMID 39253360 · DOI 10.3389/fneur.2024.1427198

Verify or expand the search:

Other recruiting trials for Ischemic Stroke, Acute

Currently open trials in the same condition.

NCT06639360 — Effects of Transcranial Magnetic Stimulation After Endovascular Treatment for Acute Ischemic Stroke · NA · recruiting
NCT07043686 — Cerebrolysin in Early Stroke Rehabilitation - Tertiary Study · NA · recruiting
NCT06920303 — Accuracy of Transcranial Colour Coded Duplex in Comparing With CT Angiography · recruiting
NCT06712004 — A Dose-Response Controlled Trial of Bevifibatide for Acute Ischemic Stroke · Phase 2 · recruiting
NCT06726941 — Effect of Exercise Gene Expression and Histone Modifications in Patients With Hemiplegia · NA · recruiting

Other University Hospital Tuebingen trials

Trials by the same sponsor.

NCT07378670 — DEfeating PEnile CAncer-2 · NA · recruiting
NCT07276503 — Verification of a New Predictive Delirium Score in Adults With Elective Cardiac Valve or Bypass Surgery With Perioperati · not yet recruiting
NCT07411365 — Dual-task Cognitive-motor Telerehabilitation in Persons With PD-MCI · NA · not yet recruiting
NCT06953791 — Comparison of Quality of Life During a Flare of Crohn's Disease Treated With Prednisolone or aCDED With PEN in Adult Pat · Phase 2 · recruiting
NCT07378891 — Artificial-Intelligence-based Early Detection of Diabetic Retinopathy (FUNDUS AI) · enrolling by invitation

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05600374 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital Tuebingen
Last refreshed: 22 November 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05600374.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing