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NCT05597683
Quadratus Lumborum Block After Cytoreductive Surgery and Hyperthermic Intra-peritoneal Chemotherapy
NA trial testing Arm I (QL block and multimodal analgesia), Arm II (multimodal analgesia without regional block) in Cytoreductive Surgery in 50 participants. Currently enrolling.
31 December 2024
Quick facts
| Lead sponsor | Gangnam Severance Hospital |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 50 |
| Start date | 15 November 2022 |
| Primary completion | 31 December 2024 |
| Estimated completion | 10 January 2025 |
| Sites | 1 location across South Korea |
Drugs / interventions tested
- Arm I (QL block and multimodal analgesia), Arm II (multimodal analgesia without regional block)
Conditions studied
- Cytoreductive Surgery — all drugs for Cytoreductive Surgery →
- Hyperthermic Intra-peritoneal Chemotherapy — all drugs for Hyperthermic Intra-peritoneal Chemotherapy →
- Peritoneal Cancer — all drugs for Peritoneal Cancer →
Sponsor
Gangnam Severance Hospital
Who can join
19 and older, any sex, with Cytoreductive Surgery or Hyperthermic Intra-peritoneal Chemotherapy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to assess whether transmusculr quadratus lomborum block (QL block) can reduce postoperative pain after cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy (CRS and HIPEC). Patients will be randomly assigned to either QL block group or control group. Ultrasound-guided bilateral transmuscular quadratus lomborum block will be performed in QL block group using 0.375% ropivacaine. Multimodal analgesic regimen including acetaminophen, nonsteroidal antiinflammatory drugs (NSAIDs), and rescue opioids will be used in every patient. Primary outcome is opioid consumption for 24 hours after surgery. Secondary outcomes included pain scores, time to first rescue analgesics, quality of recovery score, length of hospital stay.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05597683
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Cytoreductive Surgery
Currently open trials in the same condition.
- NCT05316181 — CRS & HIPEC for Platinum-Resistant Recurrent Ovarian Cancer (KOV-02R, RECOVER) · Phase 3 · active not recruiting
Other Gangnam Severance Hospital trials
Trials by the same sponsor.
- NCT07505628 — AI-based Rehabilitation for Hip and Knee Surgery Patients · NA · not yet recruiting
- NCT07311122 — Endocrine Therapy Base on 21-gene RS · not yet recruiting
- NCT07011823 — Immune-checkpoint Blockade After Partial Breast Irradiation by Pembrolizumab in Early TNBC · Phase 2 · not yet recruiting
- NCT07211451 — Axillary Nodal Burden in HER2+ and TNBC · completed
- NCT06839716 — Comparison of Ropivacaine-Poloxamer 407 Hydrogel and TAP Block for Postoperative Pain Management in Laparoscopic/Robotic · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05597683 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Gangnam Severance Hospital
- Last refreshed: 15 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05597683.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing