NCT05595122 (SCORPION-II-p) is a NA clinical trial of EUS-CDS in Biliary Obstruction, sponsored by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA).

Who is sponsoring NCT05595122?

NCT05595122 is sponsored by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA).

What drugs are being tested in NCT05595122?

Interventions in NCT05595122: EUS-CDS.

What condition does NCT05595122 study?

NCT05595122 studies Biliary Obstruction, Pancreas Neoplasm, Distal Cholangiocarcinoma.

Is NCT05595122 still recruiting?

NCT05595122 is currently status unknown. Last updated 20 July 2023.

Last reviewed 2023-07-20 · How we verify

NCT05595122: SCORPION-II-p

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

EUS-guided Choledochoduodenostomy for Primary Drainage of Malignant Distal Biliary Obstruction

Status unknown NA Last updated 20 July 2023

What this trial tests

NA trial testing EUS-CDS in Biliary Obstruction in 25 participants. Status unknown.

Timeline

2 December 2022

Primary endpoint
30 September 2023

1 March 2024

Quick facts

Lead sponsor	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	25
Start date	2 December 2022
Primary completion	30 September 2023
Estimated completion	1 March 2024
Sites	1 location across Netherlands

Drugs / interventions tested

EUS-CDS

Conditions studied

Biliary Obstruction — all drugs for Biliary Obstruction →
Pancreas Neoplasm — all drugs for Pancreas Neoplasm →
Distal Cholangiocarcinoma — all drugs for Distal Cholangiocarcinoma →

Sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) — full company profile →

Who can join

18 and older, any sex, with Biliary Obstruction or Pancreas Neoplasm. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A prospective single-centre pilot study investigating the feasibility and safety of EUS-guided choledochostomy as primary drainage strategy in patients with distal malignant biliary obstruction using a FCSEMS through LAMS to reduce stent dysfunction.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Optimizing EUS-guided choledochoduodenostomy with lumen-apposing metal stents for primary drainage of malignant distal biliary obstruction (SCORPION-IIp): a prospective pilot study.
Fritzsche JA, Fockens P, Besselink MG, Busch OR, et al · · 2025 · cited 12× · PMID 39424003 · DOI 10.1016/j.gie.2024.10.012
Advances in Endoscopic Management of Distal Biliary Stricture: Integrating Clinical Evidence into Patient-Specific Decision-Making.
Yamada R, Miwata T, Nakamura Y, Nose K, et al · · 2025 · cited 1× · PMID 40867273 · DOI 10.3390/cancers17162644

Verify or expand the search:

Other recruiting trials for Biliary Obstruction

Currently open trials in the same condition.

NCT06620328 — Safety and Efficacy of Mechanical Versus Electrocautery Dilator for EUS-guided Biliary Drainage (MED-BD) · NA · recruiting
NCT07407491 — Comparative Efficacy Of Intraductal Antibiotic During ERCP In Acute Cholangitis · Phase 2 · recruiting
NCT06287112 — Prevention of Acute Cholecystitis With ETGBD · NA · recruiting
NCT04857424 — Quality of Life Assessment Between Internal Endoscopic Versus Percutaneous Drainage in Biliary Obstruction · active not recruiting
NCT04813055 — Prospective Registry Of Therapeutic EndoscopiC ulTrasound · recruiting

Other Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) trials

Trials by the same sponsor.

NCT07301021 — Velopharyngeal Insufficiency After Maxillomandibular Advancement Osteotomy in Obstructive Sleep Apnea Patients · not yet recruiting
NCT07359482 — sElective Serotonin reuPtake inhibitoRs In posT-covid After COVID-19 · Phase 3 · not yet recruiting
NCT07457957 — Effectiveness of an mHealth Innovation on the Impact of Menstrual Complaints in Adolescents · NA · not yet recruiting
NCT06909045 — Adaptive vs. Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease · NA · recruiting
NCT07316127 — Immunoadsorption in Autoimmune Long COVID · Phase 2 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05595122 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Last refreshed: 20 July 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05595122.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing