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NCT05593679
A Multi-center Cardiac PYP Scan Registry in Taiwan
trial testing Tc-99m PYP Cardiac scan in Heart Failure in 1,000 participants. Currently enrolling.
29 August 2027
Quick facts
| Lead sponsor | Far Eastern Memorial Hospital |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 1,000 |
| Start date | 1 November 2022 |
| Primary completion | 29 August 2027 |
| Estimated completion | 31 December 2027 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
- Tc-99m PYP Cardiac scan
Conditions studied
- Heart Failure — all drugs for Heart Failure →
- Cardiac Amyloidosis — all drugs for Cardiac Amyloidosis →
Sponsor
Far Eastern Memorial Hospital
Who can join
20 and older, any sex, with Heart Failure or Cardiac Amyloidosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Amyloid deposition in the heart is called cardiac amyloidosis (CA); 95% is immunoglobulin light chain amyloidosis (AL) and transthyretin amyloidosis (ATTR). Hereditary (ATTRm) or wild-type (ATTRwt) depends on whether the ATTRm gene is mutated or not. The most common mutation in Taiwan is A97S, 80% have left ventricular hypertrophy. The good prognosis depends on early diagnosis and correct treatment strategy. Bone-avid tracers such as 99mTc-PYP/DPD/HMDP could detect CA. The mechanism is not clear yet, which may be related to the microcalcification. AL amyloidosis is mostly between visual score grade 0-2, and ATTR-CM is usually grade≥2 on PYP scan, or heart to contralateral (H/CL) ratio, and it might replace invasive myocardial biopsy. However, there are no large-scale clinical studies, lack of standardization data, and limited information in comparison between clinical and imaging parameters. The project will enroll patients with suspected or diagnosed with CA according to CA diagnostic algorithm. Clinical data and image parameters are collected and compared. The project aims to set up prediction models based on the multi-parameters of PYP scan using artificial intelligence technology, including imaging registration and alignment technology, and standardization. The investigators further use the key cardiovascular data elements and imaging-derived database using model training network to extract image features to develop the diagnostic and prognostic prediction models, which are expected to validate the clinical significance and improve patient-centric performance and efficient clinical decision making.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05593679
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Other Far Eastern Memorial Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05593679 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Far Eastern Memorial Hospital
- Last refreshed: 29 July 2024
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