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NCT05592431
Effect of Volume Guarantee-High Frequency Oscillatory Ventilation on Cerebral Blood Flow in Neonates
NA trial testing High Frequency Oscillatory Ventilation with Volume Guarantee (SLE6000;SLE) in Infant, Premature, Diseases in 60 participants. Completed in 30 August 2024.
30 May 2024
Quick facts
| Lead sponsor | Ain Shams University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | diagnostic |
| Enrollment | 60 |
| Start date | 27 October 2022 |
| Primary completion | 30 May 2024 |
| Estimated completion | 30 August 2024 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- High Frequency Oscillatory Ventilation with Volume Guarantee (SLE6000;SLE)
- High Frequency Oscillatory Ventilation (SLE6000;SLE)
Conditions studied
- Infant, Premature, Diseases — all drugs for Infant, Premature, Diseases →
- Respiratory Tract Diseases — all drugs for Respiratory Tract Diseases →
- Cerebral Blood Flow — all drugs for Cerebral Blood Flow →
Sponsor
Ain Shams University
Who can join
Adults 1 Day to 1 Month, any sex, with Infant, Premature, Diseases or Respiratory Tract Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A randomized controlled clinical trial evaluates cerebral blood flow changes associated with HFOV-VG in comparison to HFOV alone in preterm neonates with respiratory insufficiency during the period of invasive respiratory support
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Volume-targeted on high-frequency oscillatory ventilation in preterm infants: a systematic review.
Orlandin EAS, Iwashita-Lages T, Oharomari-Junior LK, Tomé MR, et al · · 2025 · PMID 40074210 · DOI 10.1016/j.jped.2025.01.012
Verify or expand the search:
- PubMed search for NCT05592431
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Infant, Premature, Diseases
Currently open trials in the same condition.
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Other Ain Shams University trials
Trials by the same sponsor.
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- NCT07482540 — Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery · NA · not yet recruiting
- NCT07531030 — Posterior Pericapsular Deep Gluteal Block Combined With Pericapsular Nerve Group and Lateral Femoral Cutaneous Nerve Blo · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05592431 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ain Shams University
- Last refreshed: 25 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05592431.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing