Last reviewed · How we verify
NCT05592028
High Intensity Focused Ultrasound for X-linked Dystonia-parkinsonism
trial testing transcranial magnetic resonance-guided focused ultrasound pallidothalamic tractotomy in X-Linked Dystonia Parkinsonism. Available.
Quick facts
| Lead sponsor | University of the Philippines Manila - Philippine General Hospital |
|---|---|
| Status | AVAILABLE |
| Study type | EXPANDED_ACCESS |
| Sites | 1 location across Philippines |
Drugs / interventions tested
- transcranial magnetic resonance-guided focused ultrasound pallidothalamic tractotomy
Conditions studied
- X-Linked Dystonia Parkinsonism — all drugs for X-Linked Dystonia Parkinsonism →
Sponsor
University of the Philippines Manila - Philippine General Hospital
Who can join
18 and older, male only, with X-Linked Dystonia Parkinsonism. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
X-linked dystonia-parkinsonism (XDP) is a rare, X-linked, adult-onset, and progressive movement disorder seen almost exclusively in men from Panay Island in the Philippines. The disease is associated with mutations involving the DYT3/TAF1 gene, and all the cases described so far have been linked to Filipino ancestry. Although XDP is very rare globally, the prevalence is 5.74 per 100,000 individuals in Panay Island and 0.31 per 100,000 in the Philippines as a whole. Majority of patients (95%) were males, and the mean age of onset was 39 years. The mean duration of illness was 16 years, and the mean age of death was 55.6 years.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Transcranial magnetic resonance-guided focused ultrasound pallidothalamic tractotomy for patients with X-linked dystonia-parkinsonism: a study protocol.
Jamora RDG, Khu KJO, Sy MCC, Pascual JSG, et al · · 2023 · cited 2× · PMID 37596524 · DOI 10.1186/s12883-023-03344-x
Verify or expand the search:
- PubMed search for NCT05592028
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05592028 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of the Philippines Manila - Philippine General Hospital
- Last refreshed: 24 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05592028.
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