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NCT05586451
Muscle Activation With Acute Bouts of Blood Flow Restricted Resistance Exercise
NA trial testing Traditional High Load Resistance Exercise (HLRE) in Muscle in 30 participants. Completed in 1 August 2023.
1 August 2023
Quick facts
| Lead sponsor | Louisiana State University and A&M College |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 30 |
| Start date | 5 July 2022 |
| Primary completion | 1 August 2023 |
| Estimated completion | 1 August 2023 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Traditional High Load Resistance Exercise (HLRE)
- Low Load Resistance Exercise with Blood Flow Restriction (LLBFR)
- Moderate Load Resistance Exercise with Blood Flow Restriction (MLBFR)
Conditions studied
- Muscle — all drugs for Muscle →
- Acute Exercise — all drugs for Acute Exercise →
Sponsor
Louisiana State University and A&M College
Who can join
Adults 18 to 40, male only, with Muscle or Acute Exercise. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Blood flow restricted (BFR) resistance exercise has been shown to improve skeletal muscle adaptations to low load resistance exercise. One of many adaptations with resistance training is neural adaptations that occur within the first few weeks of resistance training. It has been hypothesized that these neural adaptations are blunted when using blood flow restricted exercise. Therefore, the investigators propose to examine the muscle activation created by resistance exercise with different intensities with blood flow restriction and without blood flow restriction in sedentary compared to resistance-trained individuals. The investigators will recruit and completely study up to 30, previously untrained and resistance-trained, healthy, college-aged (18-40 years) males. Participants will come in the laboratory for 5 total visits. These visits will consist of a screening/familiarization visit, a strength testing visit, and 3 acute exercise visits. The acute exercise visits will consist of 2 blood flow restricted resistance sessions at different intensities and a traditional high load resistance exercise session. The 3 acute exercise visits will be randomized. The investigators will measure muscle mass (appendicular lean mass) using Dual Energy X-Ray Absorptiometry, muscle strength and endurance using isotonic and isokinetic testing, and muscle activation using surface electromyography. The investigators will also use near infrared spectroscopy (NIRS) to measure the muscle tissue (oxygen) saturation index (TSI) in the vastus lateralis during exercise. Finally, the investigators will also draw blood before and after each exercise session to measure hormones, metabolites, and markers of inflammation using commercially available assays (e.g., ELISAs).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effect of training status on muscle excitation and neuromuscular fatigue with resistance exercise with and without blood flow restriction in young men.
Davis BH, Spielmann G, Johannsen NM, Fairchild V, et al · · 2025 · cited 2× · PMID 40110914 · DOI 10.14814/phy2.70274
Verify or expand the search:
- PubMed search for NCT05586451
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05586451 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Louisiana State University and A&M College
- Last refreshed: 13 September 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05586451.
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