Last reviewed · How we verify
NCT05584358: BABE
Protein Extrusion and Postprandial Amino Acid Handling
NA trial testing Dry protein blend ingestion in Postprandial Plasma Amino Acid Availability in 9 participants. Completed in 31 August 2023.
31 August 2023
Quick facts
| Lead sponsor | University of Exeter |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | basic science |
| Enrollment | 9 |
| Start date | 2 February 2022 |
| Primary completion | 31 August 2023 |
| Estimated completion | 31 August 2023 |
| Sites | 2 locations across United Kingdom |
Drugs / interventions tested
- Dry protein blend ingestion
- Extruded protein blend ingestion
Conditions studied
- Postprandial Plasma Amino Acid Availability — all drugs for Postprandial Plasma Amino Acid Availability →
Sponsor
University of Exeter
Who can join
Adults 18 to 40, any sex, with Postprandial Plasma Amino Acid Availability. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The bulk of research that has investigated the effect of dietary protein on muscle tissue in humans has used isolated, minimally processed protein powders. However, the protein that we consume on a daily basis has typically undergone various processing methods, and evidence suggests these can change the way our bodies metabolise the protein. 'Extrusion' is a common processing method that uses high pressure to produce protein containing cereals and meat replacement foods. There is currently no research looking at how extrusion affects the way a protein source is digested and absorbed in humans. This study will compare the availability of ingested protein in the blood in the hours following consumption of an extruded versus a non-extruded source.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
High-Moisture Extrusion of a Dietary Protein Blend Impairs In Vitro Digestion and Delays In Vivo Postprandial Plasma Amino Acid Availability in Humans.
West S, Monteyne AJ, Whelehan G, Abdelrahman DR, et al · · 2024 · cited 5× · PMID 38797481 · DOI 10.1016/j.tjnut.2024.05.018
Verify or expand the search:
- PubMed search for NCT05584358
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05584358 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Exeter
- Last refreshed: 11 January 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05584358.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing