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NCT05583643
Clinical & Biochemical Effect of Atorvastatin in Nano Particles Gel in Periodontitis Treatment
Phase 1 trial testing Atorvastatin Calcium in Periodontitis in 24 participants. Completed in 30 June 2022.
15 April 2022
Quick facts
| Lead sponsor | Misr University for Science and Technology |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 24 |
| Start date | 7 December 2021 |
| Primary completion | 15 April 2022 |
| Estimated completion | 30 June 2022 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Atorvastatin Calcium (Atorvastatin Calcium) — full drug profile →
- Atorvastatin Calcium (Atorvastatin Calcium) — full drug profile →
- Scaling and debridement only
Conditions studied
- Periodontitis — all drugs for Periodontitis →
Sponsor
Misr University for Science and Technology
Who can join
Adults 25 to 45, any sex, with Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Periodontitis is a destructive chronic inflammatory disease characterized by periodontium damage and pocket formation between the tooth and the gingival margin resulting in ultimate tooth loss. Various topical anti-inflammatory drugs were used to treat inflammation in periodontitis. Introducing atorvastatin as a novel remedy for periodontitis treatment necessitates developing a syringeable modified delivery system capable of targeting inflammation within the periodontal pockets.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Bioresponsive engineered nanoparticles for immunomodulation.
Hegde M, Mishra A, Banerjee R, Bintee B, et al · · 2025 · cited 4× · PMID 41162977 · DOI 10.1186/s12916-025-04305-6
Verify or expand the search:
- PubMed search for NCT05583643
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Periodontitis
Currently open trials in the same condition.
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Other Misr University for Science and Technology trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05583643 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Misr University for Science and Technology
- Last refreshed: 19 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05583643.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing