NCT05582642 is a NA clinical trial of Inspiratory Muscle Training (IMT) in COVID-19, sponsored by RWTH Aachen University.

Who is sponsoring NCT05582642?

NCT05582642 is sponsored by RWTH Aachen University.

What drugs are being tested in NCT05582642?

Interventions in NCT05582642: Inspiratory Muscle Training (IMT).

What condition does NCT05582642 study?

NCT05582642 studies COVID-19, Diaphragm Injury.

Is NCT05582642 still recruiting?

NCT05582642 is currently completed. Last updated 28 January 2026.

Last reviewed 2026-01-28 · How we verify

NCT05582642

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Respiratory Muscles After Inspiratory Muscle Training After COVID-19

Completed NA Last updated 28 January 2026

What this trial tests

NA trial testing Inspiratory Muscle Training (IMT) in COVID-19 in 18 participants. Completed in 1 June 2024.

Timeline

17 October 2022

Primary endpoint
1 June 2024

1 June 2024

Quick facts

Lead sponsor	RWTH Aachen University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	18
Start date	17 October 2022
Primary completion	1 June 2024
Estimated completion	1 June 2024
Sites	1 location across Germany

Drugs / interventions tested

Inspiratory Muscle Training (IMT)

Conditions studied

COVID-19 — all drugs for COVID-19 →
Diaphragm Injury — all drugs for Diaphragm Injury →

Sponsor

RWTH Aachen University

Who can join

Adults 18 to 80, any sex, with COVID-19 or Diaphragm Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

It is the aim of the current (follow-up) project for the first time in post-COVID-19 patients who continue to complain of shortness of breath and for whom there is no other explanation than possibly proven diaphragmatic weakness, to determine the effects of 6 weeks of IMT/diaphragm training on diaphragm strength and shortness of breath.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Potential Diaphragm Muscle Weakness-related Dyspnea Persists 2 Years after COVID-19 and Could Be Improved by Inspiratory Muscle Training: Results of an Observational and an Interventional Clinical Trial.
Spiesshoefer J, Regmi B, Senol M, Jörn B, et al · · 2024 · cited 11× · PMID 38763165 · DOI 10.1164/rccm.202309-1572oc

Verify or expand the search:

Other trials of Inspiratory Muscle Training (IMT)

Trials testing the same drug.

NCT07188675 — Functional Inspiratory Training in Bronchiectasis · NA · recruiting
NCT07024095 — Inspiratory Muscle Training After Vertebroplasty in Osteoporotic Fracture Patients · NA · not yet recruiting
NCT04566172 — Preoperative Optimization to Improve Functional Status · NA · withdrawn
NCT06576297 — Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure · NA · active not recruiting
NCT06286553 — Rehabilitation of Abdominal Diastasis After Childbirth: Trunk and Inspiratory Muscle Training · NA · recruiting

Other recruiting trials for COVID-19

Currently open trials in the same condition.

NCT07183709 — Safety and Immunogenicity Trial of PepGNP-COVID19 Vaccine in Adults · Phase 1 · active not recruiting
NCT07300839 — A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age · Phase 3 · active not recruiting
NCT07221162 — A Safety and Immunogenicity Trial of Boost-2867 Vaccine, Via Intranasal and Intramuscular Routes · Phase 1 · recruiting
NCT07215520 — Safety and Tolerability of a Newcastle Disease Virus-Based Mucosal COVID-19 Vaccine in Previously Vaccinated Adults · Phase 2 · recruiting
NCT07222384 — A Study to Learn About BNT162b2 (LP.8.1)-Adapted Vaccine Against SARS-CoV-2 in Children 5 Through 11 Years of Age That A · Phase 3 · active not recruiting

Other RWTH Aachen University trials

Trials by the same sponsor.

NCT06390384 — Prevention Programme for Improvement of Well-being and Level of Participation in Adolescents With Enhanced Psychiatric B · NA · not yet recruiting
NCT07322796 — Smoking Cessation Before Bronchoscopy or CT-guided Puncture · recruiting
NCT04996914 — Adjuvant Stereotactic Body Radiation Therapy After Trans-arterial Chemoembolization in Hepatocellular Carcinoma · NA · not yet recruiting
NCT07053956 — Impact of Chewing Gum on FeNO Levels in Patients With Bronchial Asthma · NA · completed
NCT07140536 — The Impact of Treadmills and Cooler Environments for Office Workplaces on Ergonomics, Heating Energy Requirements, Perfo · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05582642 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by RWTH Aachen University
Last refreshed: 28 January 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05582642.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing